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Lercanidipine hydrochloride

Description Source Background
Product Name
Lercanidipine hydrochloride
CAS No.
132866-11-6
Chemical Name
Lercanidipine hydrochloride
Synonyms
LERCANIDIPINE HCL;CLAP;mE10;R 75;BCL10;c-E10;CIPER;IMD37;CarMen;Lercan
CBNumber
CB0371085
Molecular Formula
C36H42ClN3O6
Formula Weight
648.19
MOL File
132866-11-6.mol
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Lercanidipine hydrochloride Property

Melting point:
175-177°C
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder
color 
yellow
Merck 
14,5446
InChIKey
WMFYOYKPJLRMJI-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC(C)(C)CN(CCC(C2=CC=CC=C2)C2=CC=CC=C2)C)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OC)=O.[H]Cl
CAS DataBase Reference
132866-11-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37-45
RIDADR 
UN 2811
WGK Germany 
3
HS Code 
2933.39.4100
Toxicity
LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6668
Product name
Lercanidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$210
Updated
2025/07/31
Sigma-Aldrich
Product number
L6668
Product name
Lercanidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$595
Updated
2025/07/31
TCI Chemical
Product number
L0282
Product name
Lercanidipine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
L0282
Product name
Lercanidipine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$44
Updated
2025/07/31
Cayman Chemical
Product number
29104
Product name
Lercanidipine (hydrochloride)
Packaging
50mg
Price
$38
Updated
2024/03/01
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Lercanidipine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Pale-Yellow Powder

Uses

long-acting dihydropyridine calcium channel blocker, antihypertensive

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Definition

ChEBI: Lercanidipine hydrochloride is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Biological Activity

L-type Ca 2+ channel blocker that displays higher vascular selectivity than Felodipine (4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester ). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive.

Biochem/physiol Actions

Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine.

Synthesis

957215-03-1

132866-11-6

The general procedure for the synthesis of 3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride from the compound (CAS:957215-03-1) is as follows: 10 mmol of oxalate salt (Example 4) was dissolved in 100 mL of dichloromethane and 20 mL of aqueous solution containing 20 mmol of potassium carbonate was added. The organic phase was separated and the aqueous phase was extracted with 2 x 10 mL of dichloromethane. The organic phase was combined and treated with 20 mL of 1N hydrochloric acid solution. The organic phase was separated and concentrated. The residue was dissolved in 2,000 mL of water and 2 mL of 1N hydrochloric acid and 5 mL of saturated aqueous sodium chloride were added to form I hydrochloride hemihydrate and the product was collected by filtration. Yield: 6.2 g (95%); Purity: 99.8% (HPLC); Melting point: 118-122 ° C. HPLC conditions: RP 16 column, 125×3 mm ID, 5 μm, Detection wavelength: 233 nm; Eluent composition: 0.01 mol Na2HPO4/MeOH/acetonitrile=25/65/10; Retention time: about 15 min.

Description

BCL10 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-233) and having a molecular mass of 28.8kDa (molecular weight on SDS-PAGE will appear higher).
BCL10 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Ecoli

Background

BCL10 holds a caspase recruitment domain (CARD), and is known as an inducer of apoptosis and as NF-kappaB activator. BCL10 cooperates with other CARD domain containing proteins such as CARD9, 10, 11 and 14, which operates as upstream regulators in NF-kappaB signaling. BCL10 is known to create a complex with MALT1, a protein encoded by another gene and is translocated in MALT lymphoma. MALT1 and BCL10 protein synergize the activation of NF-kappaB, and the deregulation of either of them facilitates the same pathogenetic process which leads to the malignancy.

References

[1] Patent: EP1860102, 2007, A1. Location in patent: Page/Page column 1; 8; 15

Lercanidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lercanidipine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Lercanidipine hydrochloride 132866-11-6
Price
US $9.90/KG
Min. Order
100KG
Purity
99%
Supply Ability
10 tons
Release date
2024-12-03
Hebei Yanxi Chemical Co., Ltd.
Product
Lercanidipine hydrochloride 132866-11-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07
Hebei Yanxi Chemical Co., Ltd.
Product
Lercanidipine hydrochloride 132866-11-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07

132866-11-6, Lercanidipine hydrochlorideRelated Search:

Dimethyl carbonate Lercanidipine Quinolinic acid Dimethyl phthalate ETHANE Dacthal 2,6-Lutidine 2,5-PYRIDINEDICARBOXYLIC ACID Dimethyl fumarate Dimethyl disulfide N,N-Dimethylallylamine Topotecan hydrochloride 2,5-Dimethylpyridine Chromium picolinate Dimethyl sulfate DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Dimethyl sulfoxide 1-AdaMantanethylaMine

  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride
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  • LERCANIDIPINE HYDROCHLORIDE
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimeth
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nittrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
  • 3-(1-((3,3-Diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,3-[2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl] 5-Methyl ester,hydrochloride (1:1)
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  • -1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
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  • 3-(1-((3,3-Diphenylpropyl)
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  • LERCANIDIPINEHYDROCHLORIDE(FORR&DONLY)
  • Lercanidipine hemihydrate hydrochloride
  • 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-[2-[3,3-diphenylpropyl(methyl)amino]-1,1-dimethyl-ethyl] ester O5-methyl ester hydrochloride
  • 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
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