HAEGTFTSDVS

HAEGTFTSDVS Property

Boiling point:

1775.9±65.0 °C(Predicted)

Density 

1.425±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

2.98±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser

Hazard and Precautionary Statements (GHS)

HAEGTFTSDVS Chemical Properties,Usage,Production

Description

HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from intestinal L-cells, in response to the ingestion of food. GLP-1 exerts multiple actions by stimulating insulin secretion from pancreatic β-cells, in a glucose dependent manner (insulinotropic action). GLP-1 lowers circulating plasma glucagon concentration, by inhibiting its secretion (production) from α-cells. GLP-1 also exhibits properties like stimulation of β-cell growth, appetite suppression, delays gastric emptying and stimulation of insulin sensitivity[1]. The peptide analogs of GLP-1 are useful as glucagon-like peptide 1 receptor agonists[2].

Uses

HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

References

[1]. US20120264685 [2]. US9738697