4-(2-THIENYL)BUTYRIC ACID
- Product Name
- 4-(2-THIENYL)BUTYRIC ACID
- CAS No.
- 4653-11-6
- Chemical Name
- 4-(2-THIENYL)BUTYRIC ACID
- Synonyms
- 2-THIOPHENEBUTYRIC ACID;4-(2-thienyl)butyricaci;2-Thiophenebutanoic acid;4-(2-THIENYL)BUTYRIC ACID;Thiophene-2-butanoic acid;2-(2-THIENYL)BUTYRIC ACID;4-(2-Thienyl)butanoic acid;4-Thiophen-2-yl-butyric acid;4-(2-Thienyl)butyricacid,98+%;4-(2-Thienyl)butyric acid, GC 97%
- CBNumber
- CB0401962
- Molecular Formula
- C8H10O2S
- Formula Weight
- 170.23
- MOL File
- 4653-11-6.mol
4-(2-THIENYL)BUTYRIC ACID Property
- Melting point:
- 13.5-15 °C
- Boiling point:
- 122°C 0,3mm
- Density
- 1.169 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.532(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.71±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.1690
- color
- Clear slightly brown
- BRN
- 127982
- CAS DataBase Reference
- 4653-11-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T27804
- Product name
- 4-(2-Thienyl)butyric acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- T27804
- Product name
- 4-(2-Thienyl)butyric acid
- Purity
- 98%
- Packaging
- 2.5g
- Price
- $74.3
- Updated
- 2023/06/20
- Product number
- T4178
- Product name
- 4-(Thiophen-2-yl)butanoic Acid
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $45
- Updated
- 2025/07/31
- Product number
- T4178
- Product name
- 4-(Thiophen-2-yl)butanoic Acid
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $135
- Updated
- 2025/07/31
- Product number
- T344130
- Product name
- 2-ThiophenebutanoicAcid
- Packaging
- 25g
- Price
- $265
- Updated
- 2021/12/16
4-(2-THIENYL)BUTYRIC ACID Chemical Properties,Usage,Production
Chemical Properties
CLEAR SLIGHTLY BROWNISH LIQUID
Uses
2-Thiophenebutanoic Acid is used to prepare cell-penetrating peptide α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. it is also used to prepare isochroman carboxylic acid derivatives as potential anti-diabetic agents.
Definition
ChEBI: A monocarboxylic acid that is butyric acid bearing a 2-thienyl group at position 4.
Synthesis
4653-08-1
4653-11-6
The general procedure for the synthesis of 4-(2-thienyl)butyric acid from 3-(2-thiophenecarbonyl)propionic acid was as follows: 4-oxo-4-(thiophen-2-yl)butyric acid (2.3 g, 12.48 mmol) was dissolved in ethylene glycol (30 mL), and hydrazine hydrate (99%, 2.2 mL, 45.9 mmol) and potassium hydroxide pellets (2.37 g, 42.4 mmol). The reaction mixture was heated to 180 °C and maintained for 10 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with water. The aqueous layer was washed with ether, acidified with 6N hydrochloric acid and extracted with ether. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 2% dichloromethane solution in methanol) to give 4-(thiophen-2-yl)butanoic acid (1.8 g, 85% yield). The product was confirmed by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 12.06 (s, 1H), 7.31-7.29 (m, 1H), 6.94-6.91 (m, 1H), 6.84-6.82 (m, 1H), 2.82-2.77 (t, J=7.7 Hz, 2H), 2.27- 2.22 (t, J=7.3Hz, 2H), 1.86-1.76 (m, 2H); MS (ESI) m/z: [M+H]+ Calculated value 170.04, measured value 170.8.
References
[1] European Journal of Medicinal Chemistry, 1998, vol. 33, # 11, p. 867 - 877
[2] Patent: WO2011/88187, 2011, A1. Location in patent: Page/Page column 60-61
[3] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1185 - 1193
[5] Archiv der Pharmazie, 1988, vol. 321, # 10, p. 735 - 738
4-(2-THIENYL)BUTYRIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-THIENYL)BUTYRIC ACID Suppliers
- Tel
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- Fax
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- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
- Tel
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- labchem-tec@wako-chem.co.jp
- Country
- Japan
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View Lastest Price from 4-(2-THIENYL)BUTYRIC ACID manufacturers
- Product
- 4-(2-Thienyl)butyric acid 4653-11-6
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-31
- Product
- 4-(2-THIENYL)BUTYRIC ACID 4653-11-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11