N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

Product Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS No.: 314054-00-7
Chemical Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Synonyms: C-176;STING inhibitor 1;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
CBNumber: CB04522191
Molecular Formula: C11H7IN2O4
Formula Weight: 358.09
MOL File: 314054-00-7.mol

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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Property

Boiling point:: 361.2±37.0 °C(Predicted)
Density: 1.935±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO (up to 25 mg/ml)
pka: 11.14±0.70(Predicted)
form: solid
color: Brown or yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2559
Product name: C-176
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $97.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2559
Product name: C-176
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $237
Updated: 2024/03/01

Cayman Chemical

Product number: 25859
Product name: C-176
Packaging: 10mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 25859
Product name: C-176
Packaging: 50mg
Price: $170
Updated: 2024/03/01

Cayman Chemical

Product number: 25859
Product name: C-176
Packaging: 25mg
Price: $90
Updated: 2024/03/01

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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties,Usage,Production

Description

C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation?via?blockade of palmitoylation at Cys91. Treatment of Trex-/-?mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.

storage

Store at -20°C

References

1)Haag?et al.?(2018),?Targeting STING with covalent small-molecule inhibitors; Nature?559?269

N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Suppliers

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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

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N-(4-iodophenyl)-5-nitro-2-furamide

STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA

314054-00-7