4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
- Product Name
- 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
- CAS No.
- 211738-66-8
- Chemical Name
- 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
- Synonyms
- AKOS B001423;ART-CHEM-BB B001423;RARECHEM AL BF 1005;methyl 4-bromo-1-methylpyrazole-3-carboxylate;methyl 4-bromo-1-methyl-pyrazole-3-carboxylate;Methyl 4-bromo-1-methyl-1H-pyrazol-3-carboxylate;methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate;4-bromo-1-methyl-1H-pyrazole-3-methyl carboxylate;4-bromo-1-methyl-3-pyrazolecarboxylic acid methyl ester;4-bromo-1-methyl-pyrazole-3-carboxylic acid methyl ester
- CBNumber
- CB0453077
- Molecular Formula
- C6H7BrN2O2
- Formula Weight
- 219.04
- MOL File
- 211738-66-8.mol
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Property
- Boiling point:
- 276.5±20.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.22±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M293813
- Product name
- Methyl4-Bromo-1-methyl-1H-pyrazole-3-carboxylate
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- M293813
- Product name
- Methyl4-Bromo-1-methyl-1H-pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- OR918037
- Product name
- Methyl4-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- OR918037
- Product name
- Methyl4-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- Y8227
- Product name
- Methyl4-bromo-1-methyl-1H-pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $191
- Updated
- 2021/12/16
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
81190-89-8
74-88-4
514816-42-3
211738-66-8
To a mixture of methyl 4-bromo-1H-pyrazole-3-carboxylate (15.0 g, 73.2 mmol) and Cs2CO3 (59.6 g, 182.9 mmol) in DMF (150 mL) was added slowly and dropwise at 0 °C under nitrogen protection iodomethane (14.7 mL, 236.0 mmol). The reaction mixture was stirred at 25 °C for 16 hours. After completion of the reaction, the mixture was filtered and the filter cake was washed with ethyl acetate (200 mL x 2). The combined filtrates were washed with water (70 mL x 4) and the aqueous phase was then back-extracted with ethyl acetate (150 mL). All organic phases were combined, dried with Na2SO4, filtered and concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography (gradient elution: petroleum ether/ethyl acetate from 100/0 to 50/50) to afford methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate (240a, 8.3 g, 51.8% yield) and methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate (240b, 7.0 g, 43.7% yield), both as white solid . 1H NMR (400 MHz, CDCl3) data for compound 240a: δ 7.48 (s, 1H), 4.15 (s, 3H), 3.93 (s, 3H). m/z (M + H) + 219.0 in MS (ESI).
References
[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 1197
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER manufacturers
- Product
- 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER 211738-66-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07