ChemicalBook > CAS DataBase List > (R)-1-N-BOC-2-CYANO-PIPERIDINE

(R)-1-N-BOC-2-CYANO-PIPERIDINE

Product Name
(R)-1-N-BOC-2-CYANO-PIPERIDINE
CAS No.
940000-26-0
Chemical Name
(R)-1-N-BOC-2-CYANO-PIPERIDINE
Synonyms
(R)-N-Boc-2-cyanopiperidine;(R)-1-Boc-2-cyanopiperidine;(R)-1-N-BOC-2-CYANO-PIPERIDINE;1-N-BOC-2-(R)-CYANO-PIPERIDINE;tert-butyl (R)-2-cyanopiperidine-1-carboxylate;(R)-TERT-BUTYL 2-CYANOPIPERIDINE-1-CARBOXYLATE;tert-butyl (2R)-2-cyanopiperidine-1-carboxylate;(2R)-2-Cyano-1-piperidinecarboxylic acid tert-butyl ester;(R)-2-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-piperidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester, (2r)-
CBNumber
CB0456609
Molecular Formula
C11H18N2O2
Formula Weight
210.27
MOL File
940000-26-0.mol
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(R)-1-N-BOC-2-CYANO-PIPERIDINE Property

Density 
1.07
storage temp. 
2-8°C
Appearance
White to off-white Solid
optical activity
Consistent with structure
CAS DataBase Reference
940000-26-0
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
3439
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0052943
Product name
(R)-1-Boc-2-Cyanopiperidine
Purity
>97.0%
Packaging
1g
Price
$73
Updated
2021/12/16
Activate Scientific
Product number
AS3822
Product name
(R)-1-Boc-2-cyanopiperidine
Purity
97+% ee
Packaging
1g
Price
$155
Updated
2021/12/16
ChemScene
Product number
CS-0052943
Product name
(R)-1-Boc-2-Cyanopiperidine
Purity
>97.0%
Packaging
5g
Price
$220
Updated
2021/12/16
Activate Scientific
Product number
AS3822
Product name
(R)-1-Boc-2-cyanopiperidine
Purity
97+% ee
Packaging
5G
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0052943
Product name
(R)-1-Boc-2-Cyanopiperidine
Purity
>97.0%
Packaging
25g
Price
$554
Updated
2021/12/16
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(R)-1-N-BOC-2-CYANO-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

848488-91-5

940000-26-0

General procedure for the synthesis of (R)-1-BOC-2-cyanopiperidine from R-N-Boc-prolinamide: b) Synthesis of 1,1-dimethylethyl (2R)-2-(aminocarbonyl)-1-pyrrolidine carboxylate. To a solution of 1,1-dimethylethyl (2R)-2-(aminocarbonyl)-1-piperidine carboxylate (269 mg, 1.17 mmol) in tetrahydrofuran (THF, 10 mL) was added sequentially triethylamine (0.33 mL, 2.34 mmol) and trifluoroacetic anhydride (0.17 mL, 1.17 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h and then concentrated under vacuum. The concentrated residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium bicarbonate solution, 0.5 N hydrochloric acid and brine. The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to afford 1,1-dimethylethyl (2R)-2-cyano-1-piperidine carboxylate (255 mg, 99% yield) as a crystalline solid. The 1H NMR (CDCl3) data of the product were as follows: δ 5.23 (br, 1H), 4.05 (br, 1H), 2.93 (br, 1H), 1.93-1.39 (m, 6H), 1.46 (s, 9H).

References

[1] Patent: WO2006/116764, 2006, A1. Location in patent: Page/Page column 121; 151

(R)-1-N-BOC-2-CYANO-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-BOC-2-CYANO-PIPERIDINE Suppliers

China 28 Germany 1 India 1 United Kingdom 1 United States 8 Global 39
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75

940000-26-0, (R)-1-N-BOC-2-CYANO-PIPERIDINERelated Search:

(R)-1-BOC-2-BENZYLPIPERAZINE tert-butyl (R)-3-(2-bromophenyl)piperidine-1-carboxylate (R)-1-N-Boc-2-methylpiperazine tert-butyl (R)-3-(4-bromophenyl)piperidine-1-carboxylate (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate (R)-1-Boc-2-propylpiperazine tert-butyl (R)-3-(3-bromophenyl)-1,4-diazepane-1-carboxylate tert-butyl (R)-3-(4-formylphenyl)piperidine-1-carboxylate N-1-Boc-2-Phenylpiperazine (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (R)-3-(4-bromophenyl)-1,4-diazepane-1-carboxylate tert-butyl (R)-3-(3-bromophenyl)piperazine-1-carboxylate tert-butyl (R)-3-(4-bromophenyl)piperazine-1-carboxylate (R)-1-Boc-2-ethylPiperazine 1-Piperidinecarboxylicacid,2-ethyl-,1,1-dimethylethylester,(2R)-(9CI) tert-Butyl (R)-2-benzylpiperidine-1-carboxylate (R)-tert-butyl 3-((methylamino)methyl)piperidine-1-carboxylate tert-butyl (R)-3-(3-ethynylphenyl)piperazine-1-carboxylate

  • (R)-2-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (R)-1-N-BOC-2-CYANO-PIPERIDINE
  • (R)-TERT-BUTYL 2-CYANOPIPERIDINE-1-CARBOXYLATE
  • 1-N-BOC-2-(R)-CYANO-PIPERIDINE
  • (R)-1-Boc-2-cyanopiperidine
  • (R)-N-Boc-2-cyanopiperidine
  • tert-butyl (2R)-2-cyanopiperidine-1-carboxylate
  • (2R)-2-Cyano-1-piperidinecarboxylic acid tert-butyl ester
  • 1-piperidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester, (2r)-
  • tert-butyl (R)-2-cyanopiperidine-1-carboxylate
  • 940000-26-0