Acrizanib
- Product Name
- Acrizanib
- CAS No.
- 1229453-99-9
- Chemical Name
- Acrizanib
- Synonyms
- LHA510;LHA 510;Acrizanib;LHA510;LHA 510;Acrizanib (LHA-510);Acrizanib, 10 mM in DMSO;5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide;N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide;1H-Indole-1-carboxamide, 5-[[6-[(methylamino)methyl]-4-pyrimidinyl]oxy]-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-
- CBNumber
- CB04667490
- Molecular Formula
- C20H18F3N7O2
- Formula Weight
- 445.4
- MOL File
- 1229453-99-9.mol
Acrizanib Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 41.67 mg/mL (93.56 mM)
- form
- Solid
- pka
- 10.53±0.46(Predicted)
- color
- Light yellow to yellow
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0030518
- Product name
- Acrizanib
- Purity
- 99.84%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0030518
- Product name
- Acrizanib
- Purity
- 99.84%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- orb573147
- Product name
- Acrizanib
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1431.4
- Updated
- 2021/12/16
- Product number
- orb573147
- Product name
- Acrizanib
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2541.5
- Updated
- 2021/12/16
- Product number
- CS-0030518
- Product name
- Acrizanib
- Purity
- 99.84%
- Packaging
- 50mg
- Price
- $2650
- Updated
- 2021/12/16
Acrizanib Chemical Properties,Usage,Production
Uses
Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2[1].
in vivo
Rat ocular PK studies with Acrizanib shows a distinctly different profile from that observed with compound 25. While prolonged exposure is once again evident in the PEC, the AUC ratio to the level of Acrizanib in plasma is markedly increased (>21000-fold higher exposure in the PEC than plasma on day 11). Furthermore, unlike 25, Acrizanib also afford much improved retina to plasma AUC exposure ratio after 10 days of dosing (598× for Acrizanib vs 0.8× for 25)[1].
IC 50
VEGFR-2: 17.4 nM (IC50)
References
[1] Adams CM, et al. The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. J Med Chem. 2018 Feb 22;61(4):1622-1635. DOI:10.1021/acs.jmedchem.7b01731
Acrizanib Preparation Products And Raw materials
Raw materials
Preparation Products
Acrizanib Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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- tp@aladdinsci.com
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- United States
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