P11
- Product Name
- P11
- CAS No.
- 848644-86-0
- Chemical Name
- P11
- Synonyms
- P11 ( (trifluoroacetate salt);L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI)
- CBNumber
- CB04796587
- Molecular Formula
- C30H48N12O9
- Formula Weight
- 720.79
- MOL File
- 848644-86-0.mol
P11 Property
- Boiling point:
- 1380.0±65.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
- form
- Powder
- pka
- 4.17±0.10(Predicted)
- color
- White to off-white
- Sequence
- H-His-Ser-Asp-Val-His-Lys-NH2
N-Bromosuccinimide Price
- Product number
- P999043
- Product name
- P11
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- B5699
- Product name
- P11
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CS-0028921
- Product name
- HSDVHK-NH2
- Purity
- 99.63%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0028921
- Product name
- HSDVHK-NH2
- Purity
- 99.63%
- Packaging
- 10mg
- Price
- $310
- Updated
- 2021/12/16
P11 Chemical Properties,Usage,Production
Uses
P11 is a useful building block in the synthesis of various pharmaceuticals
Enzyme inhibitor
This potent PDZ motif-containing anti-angiogenic agent (FW = 720.78 g/mol; CAS 848644-86-0; Sequence: HSDVHK-NH2) targets the integrin αvβ3-vitronectin interaction, blocking proliferation and inducing apoptosis in human vascular endothelial cells (HUVECs). Arg-Gly-Asp (or RGD) binding-site recognition by P11 is site-specific, showing a strong antagonism against αvβ3-vitronectin interaction, IC50 = 26 nM. The binding orientation of docked P11 in αvβ3 is similar to that for RGD, suggesting a divalent metal-ion coordination is a common driving force for the formation of both SDV·αvβ3 and RGD·αvβ3 complexes. P11 appears to inhibit b-Fibroblast Growth Factor (or bFGF) -induced HUVEC proliferation via mitogen-activated protein kinase kinase and extracellular- signal regulated kinase inhibition as well as p53-mediated apoptosis related with activation of caspases. (Note: Consisting of 80-90 amino-acids in far-flung signaling proteins and binding to short C-terminal regions in protein interaction partners, “PDZ” is an acronym that includes the first letters of Post-synaptic density protein (PSD95), Drosophila Dlg1 tumor suppressor, and Zonula occludens-1 protein (zo-1), the first proteins discovered to share this domain.)
IC 50
αvβ3: 2.74 nM (IC50)