ChemicalBook > CAS DataBase List > 3-Deazaadenosine (hydrochloride)

3-Deazaadenosine (hydrochloride)

Product Name
3-Deazaadenosine (hydrochloride)
CAS No.
86583-19-9
Chemical Name
3-Deazaadenosine (hydrochloride)
Synonyms
3-Deaza-rA?HCl;3-Deazaadenosine HCl;3-Deazaadenosine (hydrochloride);3-Deazaadenosine hydrochloride, 10 mM in DMSO;1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride;(2R,3R,4S,5R)-2-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride;HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit
CBNumber
CB04797014
Molecular Formula
C11H15ClN4O4
Formula Weight
302.72
MOL File
86583-19-9.mol
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3-Deazaadenosine (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30969
Product name
3-Deazaadenosine (hydrochloride)
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
30969
Product name
3-Deazaadenosine (hydrochloride)
Packaging
10mg
Price
$365
Updated
2024/03/01
Cayman Chemical
Product number
30969
Product name
3-Deazaadenosine (hydrochloride)
Packaging
5mg
Price
$220
Updated
2024/03/01
ApexBio Technology
Product number
B8470
Product name
3-Deazaadenosinehydrochloride
Packaging
1mg
Price
$43
Updated
2021/12/16
ChemScene
Product number
CS-0069568
Product name
3-Deazaadenosinehydrochloride
Purity
98.06%
Packaging
1mg
Price
$160
Updated
2021/12/16
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3-Deazaadenosine (hydrochloride) Chemical Properties,Usage,Production

Uses

3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 μM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

Biological Activity

3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with a Ki value of 3.9 μM.

in vitro

3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 μM, respectively.

target

TargetValue
S-adenosylhomocysteine hydrolase
(Cell-free assay)		 3.9 μM(Ki)

IC 50

HIV-1

References

[1] Gordon RK, et al. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. DOI:10.1046/j.1432-1033.2003.03726.x
[2] Jeong SY, et al. 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem. 1999 Jul 2;274(27):18981-8. DOI:10.1074/jbc.274.27.18981
[3] Sedding DG, et al. 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling. Circ Res. 2009 May 22;104(10):1192-200. DOI:10.1161/CIRCRESAHA.109.194357

3-Deazaadenosine (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Deazaadenosine (hydrochloride) Suppliers

China 32 United States 7 Global 39
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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View Lastest Price from 3-Deazaadenosine (hydrochloride) manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
3-Deazaadenosine (hydrochloride) 86583-19-9
Price
US $0.00-0.00/G
Min. Order
1G
Purity
97%
Supply Ability
2000
Release date
2025-05-30

86583-19-9, 3-Deazaadenosine (hydrochloride)Related Search:


  • 3-Deazaadenosine (hydrochloride)
  • 3-Deaza-rA?HCl
  • HIV,3-Deazaadenosine,Human immunodeficiency virus,Inhibitor,3 Deazaadenosine hydrochloride,3Deazaadenosine hydrochloride,inhibit
  • 1H-Imidazo[4,5-c]pyridin-4-amine,1-β-Dribofuranosyl-,monohydrochloride
  • (2R,3R,4S,5R)-2-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride
  • 3-Deazaadenosine hydrochloride, 10 mM in DMSO
  • 3-Deazaadenosine HCl
  • 86583-19-9