CCT020312

Product Name: CCT020312
CAS No.: 324759-76-4
Chemical Name: CCT020312
Synonyms: CCT020312;CCT-020312,CCT020312;EIF2AK3 Activator, CCT020312;2(1H)-Quinolinone, 6-bromo-3-[5-(4-bromophenyl)-1-[3-(diethylamino)-1-oxopropyl]-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-
CBNumber: CB04844628
Molecular Formula: C31H30Br2N4O2
Formula Weight: 650.4
MOL File: 324759-76-4.mol

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CCT020312 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 9.43±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324879
Product name: EIF2AK3 Activator, CCT020312
Purity: The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.
Packaging: 5 mg
Price: $214
Updated: 2025/07/31

ChemScene

Product number: CS-0077300
Product name: CCT020312
Purity: 98.97%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0077300
Product name: CCT020312
Purity: 98.97%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0077300
Product name: CCT020312
Purity: 98.97%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0077300
Product name: CCT020312
Purity: 98.97%
Packaging: 5mg
Price: $160
Updated: 2021/12/16

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CCT020312 Chemical Properties,Usage,Production

Uses

CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.

Biological Activity

CCT020312 is a selective activator of EIF2AK3/PERK. It induces phosphorylation of EIF2A in cells.

in vitro

CCT020312 treatment effectively inhibits cell proliferation (as measured at 96 hours) even if treatment is for 2 hours only with subsequent compound washout, indicating that CCT020312 is capable of eliciting durable rather than transient cytostasis.

in vivo

Treatment of 15-week-old wildtype mice with the PERK activator CCT020312 (1-5 mg/kg; i.p.; once daily for 3 days) leads to increased levels of phosphorylated PERK and NRF2 in brain homogenates^[2].
P301S transgenic mice treated with CCT020312 (2 mg/kg; i.p.; once daily for 6 weeks) performes significantly better in Morris water maze^[2].

Animal Model:	9-week-old P301S tau transgenic mice^[2]
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection; once daily for 6 weeks
Result:	P301S transgenic mice treated with CCT020312 performed significantly better in Morris water maze.

target

EIF2AK3/PERK.

References

[1] Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568. DOI:10.1371/journal.pone.0028568
[2] Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9(3):371-384. DOI:10.15252/emmm.201606664

CCT020312 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT020312 Suppliers

China 28 United States 6 Global 34

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324759-76-4, CCT020312Related Search:

CCT020312

2(1H)-Quinolinone, 6-bromo-3-[5-(4-bromophenyl)-1-[3-(diethylamino)-1-oxopropyl]-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-

CCT-020312,CCT020312

EIF2AK3 Activator, CCT020312

324759-76-4

C31H30Br2N4O2