KGA2727

Product Name: KGA2727
CAS No.: 666842-36-0
Chemical Name: KGA2727
Synonyms: KGA2727;KGA-2727, 10 mM in DMSO;Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-;insulin,inhibit,Sodium-dependent glucose cotransporters,hyperglycemia,SGLT,antidiabetic,first,glucose,KGA 2727,KGA-2727,Inhibitor,SGLT1,KGA2727,orally;3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide
CBNumber: CB04919870
Molecular Formula: C26H40N4O8
Formula Weight: 536.63
MOL File: 666842-36-0.mol

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KGA2727 Property

Boiling point:: 839.6±65.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
pka: 12.65±0.70(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0085818
Product name: KGA-2727
Purity: 99.06%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0085818
Product name: KGA-2727
Purity: 99.06%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0085818
Product name: KGA-2727
Purity: 99.06%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0085818
Product name: KGA-2727
Purity: 99.06%
Packaging: 100mg
Price: $2550
Updated: 2021/12/16

DC Chemicals

Product number: DC22752
Product name: KGA-2727
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

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KGA2727 Chemical Properties,Usage,Production

Uses

KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 has antidiabetic efficacy[1].

in vivo

In the oral glucose tolerance test with streptozotocin-induced diabetic rats, KGA-2727 attenuates the elevation of plasma glucose after glucose loading, indicating that KGA-2727 improves postprandial hyperglycemia^[1].
In Zucker diabetic fatty (ZDF) rats, chronic treatments with KGA-2727 reduces the levels of plasma glucose and glycated hemoglobin. Furthermore, KGA-2727 preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats^[1].

References

[1] Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96. DOI:10.1124/jpet.112.193045

KGA2727 Preparation Products And Raw materials

Raw materials

Preparation Products

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KGA2727 Suppliers

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666842-36-0, KGA2727Related Search:

KGA2727

Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-

insulin,inhibit,Sodium-dependent glucose cotransporters,hyperglycemia,SGLT,antidiabetic,first,glucose,KGA 2727,KGA-2727,Inhibitor,SGLT1,KGA2727,orally

3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide

KGA-2727, 10 mM in DMSO

666842-36-0