KGA2727
- Product Name
- KGA2727
- CAS No.
- 666842-36-0
- Chemical Name
- KGA2727
- Synonyms
- KGA2727;KGA-2727, 10 mM in DMSO;Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-;insulin,inhibit,Sodium-dependent glucose cotransporters,hyperglycemia,SGLT,antidiabetic,first,glucose,KGA 2727,KGA-2727,Inhibitor,SGLT1,KGA2727,orally;3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide
- CBNumber
- CB04919870
- Molecular Formula
- C26H40N4O8
- Formula Weight
- 536.63
- MOL File
- 666842-36-0.mol
KGA2727 Property
- Boiling point:
- 839.6±65.0 °C(Predicted)
- Density
- 1.308±0.06 g/cm3(Predicted)
- pka
- 12.65±0.70(Predicted)
- form
- Solid
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- CS-0085818
- Product name
- KGA-2727
- Purity
- 99.06%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0085818
- Product name
- KGA-2727
- Purity
- 99.06%
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-0085818
- Product name
- KGA-2727
- Purity
- 99.06%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0085818
- Product name
- KGA-2727
- Purity
- 99.06%
- Packaging
- 100mg
- Price
- $2550
- Updated
- 2021/12/16
- Product number
- DC22752
- Product name
- KGA-2727
- Purity
- >98%
- Packaging
- 100mg
- Price
- $850
- Updated
- 2021/12/16
KGA2727 Chemical Properties,Usage,Production
Uses
KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 has antidiabetic efficacy[1].
in vivo
In the oral glucose tolerance test with streptozotocin-induced diabetic rats, KGA-2727 attenuates the elevation of plasma glucose after glucose loading, indicating that KGA-2727 improves postprandial hyperglycemia[1].
In Zucker diabetic fatty (ZDF) rats, chronic treatments with KGA-2727 reduces the levels of plasma glucose and glycated hemoglobin. Furthermore, KGA-2727 preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats[1].
References
[1] Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96. DOI:10.1124/jpet.112.193045
KGA2727 Preparation Products And Raw materials
Raw materials
Preparation Products
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