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KGA2727

Product Name
KGA2727
CAS No.
666842-36-0
Chemical Name
KGA2727
Synonyms
KGA2727;KGA-2727, 10 mM in DMSO;Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-;insulin,inhibit,Sodium-dependent glucose cotransporters,hyperglycemia,SGLT,antidiabetic,first,glucose,KGA 2727,KGA-2727,Inhibitor,SGLT1,KGA2727,orally;3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide
CBNumber
CB04919870
Molecular Formula
C26H40N4O8
Formula Weight
536.63
MOL File
666842-36-0.mol
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KGA2727 Property

Boiling point:
839.6±65.0 °C(Predicted)
Density 
1.308±0.06 g/cm3(Predicted)
pka
12.65±0.70(Predicted)
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0085818
Product name
KGA-2727
Purity
99.06%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0085818
Product name
KGA-2727
Purity
99.06%
Packaging
10mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-0085818
Product name
KGA-2727
Purity
99.06%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0085818
Product name
KGA-2727
Purity
99.06%
Packaging
100mg
Price
$2550
Updated
2021/12/16
DC Chemicals
Product number
DC22752
Product name
KGA-2727
Purity
>98%
Packaging
100mg
Price
$850
Updated
2021/12/16
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KGA2727 Chemical Properties,Usage,Production

Uses

KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 has antidiabetic efficacy[1].

in vivo

In the oral glucose tolerance test with streptozotocin-induced diabetic rats, KGA-2727 attenuates the elevation of plasma glucose after glucose loading, indicating that KGA-2727 improves postprandial hyperglycemia[1].
In Zucker diabetic fatty (ZDF) rats, chronic treatments with KGA-2727 reduces the levels of plasma glucose and glycated hemoglobin. Furthermore, KGA-2727 preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats[1].

References

[1] Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96. DOI:10.1124/jpet.112.193045

KGA2727 Preparation Products And Raw materials

Raw materials

Preparation Products

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KGA2727 Suppliers

China 34 United States 3 Global 37
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58

666842-36-0, KGA2727Related Search:


  • KGA2727
  • Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-
  • insulin,inhibit,Sodium-dependent glucose cotransporters,hyperglycemia,SGLT,antidiabetic,first,glucose,KGA 2727,KGA-2727,Inhibitor,SGLT1,KGA2727,orally
  • 3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide
  • KGA-2727, 10 mM in DMSO
  • 666842-36-0