ChemicalBook > CAS DataBase List > 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

Product Name: 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
CAS No.: 187325-53-7
Chemical Name: 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
Synonyms: GSK-3β inhibitor 1;(Z)-3-(Pyridin-2-ylmethylene)indolin-2-one;(3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-;GSK-3,inhibit,Glycogen synthase kinase 3,Glycogen synthase kinase-3,GSK3β inhibitor 1,GSK-3β inhibitor 1,Inhibitor,GSK 3β inhibitor 1
CBNumber: CB05482665
Molecular Formula: C14H10N2O
Formula Weight: 222.24
MOL File: 187325-53-7.mol

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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Property

Boiling point:: 457.2±45.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.34±0.20(Predicted)
form: Solid
color: Yellow to orange
InChI: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChIKey: YKQONSWBHGBDSB-XFXZXTDPSA-N
SMILES: N1C2=C(C=CC=C2)/C(=C/C2=NC=CC=C2)/C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090785
Product name: GSK-3βinhibitor1
Purity: 98.07%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0090785
Product name: GSK-3βinhibitor1
Purity: 98.07%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0090785
Product name: GSK-3βinhibitor1
Purity: 98.07%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Chemical Properties,Usage,Production

Uses

GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats[1].

in vivo

GSK-3β inhibitor 1 (50 mg/kg, i.p., 30 min prior to glucose challenge) effectively prevents increase in blood glucose levels in HFD+STZ diabetic rats^[1].

Animal Model:	HFD+STZ diabetic rats ^[1].
Dosage:	50 mg/kg
Administration:	i.p., 30 min prior to glucose challenge
Result:	Vehicle-treated diabetic rats developed persistent hyperglycemic response. Administration of GSK-3β inhibitor 1 30 min prior to glucose challenge effectively prevented increase in blood glucose levels.

IC 50

GSK-3β: 4.9 nM (IC₅₀)

References

[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028

2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Preparation Products And Raw materials

Raw materials

Preparation Products

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187325-53-7, 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-Related Search:

2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

GSK-3β inhibitor 1

GSK-3,inhibit,Glycogen synthase kinase 3,Glycogen synthase kinase-3,GSK3β inhibitor 1,GSK-3β inhibitor 1,Inhibitor,GSK 3β inhibitor 1

(Z)-3-(Pyridin-2-ylmethylene)indolin-2-one

(3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one

187325-53-7