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MIK-8719

Product Name
MIK-8719
CAS No.
1382799-40-7
Chemical Name
MIK-8719
Synonyms
MK-8719;MIK-8719;MK-8719 ，S8890;MK-8719, 10 mM in DMSO;MK 8719,inhibit,MK-8719,MK8719,Inhibitor;(3aR,5S,6S,7R,7aR)-5-(Difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol;5H-Pyrano[3,2-d]thiazole-6,7-diol, 5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-, (3aR,5S,6S,7R,7aR)-
CBNumber
CB05581733
Molecular Formula
C9H14F2N2O3S
Formula Weight
268.28
MOL File
1382799-40-7.mol
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MIK-8719 Property

Boiling point:
431.4±55.0 °C(Predicted)
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (372.74 mM; Need ultrasonic)
pka
12.72±0.70(Predicted)
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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MIK-8719 Chemical Properties,Usage,Production

Uses

MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].

in vivo

MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].

References

[1] Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. DOI:10.1021/acs.jmedchem.9b01090

MIK-8719 Preparation Products And Raw materials

Raw materials

Preparation Products

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MIK-8719 Suppliers

China 33 United States 3 Global 36
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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ShangHai Biochempartner Co.,Ltd
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Chuzhou KeMail Chemical Technology Co., Ltd
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Zhejiang J&C Biological Technology Co.,Limited
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+1-2135480471
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sales@sarms4muscle.com
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ShangHai ChuanQian Chemcial Technique Centre
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15869524721
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3525679403@qq.com
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Nantong Hi-Future Biotechnology Co., Ltd
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JinOu Biomedical (Nanjing) Co., Ltd.
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jinoupharma@163
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jinoupharma@163.com
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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product02@bidepharm.com
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TargetMol Chemicals Inc.
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Shanghai Tachizaki Biomedical Research Center
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Nantong QuanYi Biotechnology Co., Ltd
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Shanghai Yifei Biotechnology Co. , Ltd.
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https://hanhongsci.com/
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Nanjing Shizhou Biology Technology Co.,Ltd
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Cayman Chemical Company
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Adooq Bioscience LLC
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Selleck Chemicals
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ATK CHEMICAL COMPANY LIMITED
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Shanghai Hanhong Scientific Co., Ltd.
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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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Nantong HI-FUTURE Biology Co., Ltd.
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Guangzhou Kegou Biotechnology Co., Ltd.
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Tianjin Baibei Biotechnology Co., Ltd.
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Biorbyt Ltd.
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Absin Bioscience Inc.
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View Lastest Price from MIK-8719 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
MIK-8719 1382799-40-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-18

1382799-40-7, MIK-8719Related Search:


  • MIK-8719
  • MK-8719
  • 5H-Pyrano[3,2-d]thiazole-6,7-diol, 5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-, (3aR,5S,6S,7R,7aR)-
  • MK 8719,inhibit,MK-8719,MK8719,Inhibitor
  • (3aR,5S,6S,7R,7aR)-5-(Difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol
  • MK-8719, 10 mM in DMSO
  • MK-8719 ，S8890
  • 1382799-40-7
  • C9H14F2N2O3S