ChemicalBook > CAS DataBase List > MIK-8719
MIK-8719
- Product Name
- MIK-8719
- CAS No.
- 1382799-40-7
- Chemical Name
- MIK-8719
- Synonyms
- MK-8719;MIK-8719;MK-8719 ，S8890;MK-8719, 10 mM in DMSO;MK 8719,inhibit,MK-8719,MK8719,Inhibitor;(3aR,5S,6S,7R,7aR)-5-(Difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol;5H-Pyrano[3,2-d]thiazole-6,7-diol, 5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-, (3aR,5S,6S,7R,7aR)-
- CBNumber
- CB05581733
- Molecular Formula
- C9H14F2N2O3S
- Formula Weight
- 268.28
- MOL File
- 1382799-40-7.mol
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MIK-8719 Property
- Boiling point:
- 431.4±55.0 °C(Predicted)
- Density
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (372.74 mM; Need ultrasonic)
- pka
- 12.72±0.70(Predicted)
- form
- Solid
- color
- White to yellow
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MIK-8719 Chemical Properties,Usage,Production
Uses
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].
in vivo
MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].
References
[1] Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. DOI:10.1021/acs.jmedchem.9b01090
MIK-8719 Preparation Products And Raw materials
Raw materials
Preparation Products
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MIK-8719 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
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View Lastest Price from MIK-8719 manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- MIK-8719 1382799-40-7
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-18