4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
- Product Name
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
- CAS No.
- 6975-44-6
- Chemical Name
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
- Synonyms
- Ethyl 4,6-dihydroxynicotinate;ethyl 2,4-dihydroxypyridine-5-carboxylate;NSC 22486;BUTTPARK 153\57-32;SPECS AC-907/34126052;2,4-Dihydroxy-5-(ethoxycar;4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER;2,4-Dihydroxy-5-(ethoxycarbonyl)pyridine;Ethyl 4,6-Dihydroxypyridine-3-carboxylate;4,6-Dihydroxynicotinic acid ethyl ester ,97%
- CBNumber
- CB0680790
- Molecular Formula
- C8H9NO4
- Formula Weight
- 183.16
- MOL File
- 6975-44-6.mol
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Property
- Melting point:
- 214-217°
- Boiling point:
- 339.4±42.0 °C(Predicted)
- Density
- 1.380
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 4.50±1.00(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C8H9NO4/c1-2-13-8(12)5-4-9-7(11)3-6(5)10/h3-4H,2H2,1H3,(H2,9,10,11)
- InChIKey
- QDHHLXABEXNRJX-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C=C(O)C=1C(OCC)=O
- CAS DataBase Reference
- 6975-44-6
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E1110
- Product name
- Ethyl 4,6-Dihydroxynicotinate
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- E1110
- Product name
- Ethyl 4,6-Dihydroxynicotinate
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $174
- Updated
- 2025/07/31
- Product number
- 046087
- Product name
- Ethyl 4,6-dihydroxynicotinate
- Purity
- >95%
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- Y9854
- Product name
- Ethyl4,6-dihydroxypyridine-3-carboxylate
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- CS-W002704
- Product name
- Ethyl 4,6-Dihydroxynicotinate
- Purity
- 99.26%
- Packaging
- 25g
- Price
- $199
- Updated
- 2021/12/16
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Ethyl 4,?6-?dihydroxynicotinate has been used as a reactant is the synthesis of pyridazinopyrimidinone and pyridopyrimidinone derivatives as PDE5 inhibitors and for the synthesis of pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Synthesis
108-24-7
105-50-0
6975-44-6
The general procedure for the synthesis of ethyl 4,6-dihydroxynicotinate from ethanoic anhydride and diethyl 1,3-acetone dicarboxylate was as follows: diethyl 3-oxoglutarate (101 g, 0.5 mol), triethyl orthoformate (81.4 g, 0.55 mol), and acetic anhydride (102 g, 1 mol) were mixed and the reaction was maintained at a temperature of 120 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and dissolved in dichloromethane (1 L). Subsequently, the solution was cooled to 0 °C, 30% ammonia (80 mL) was slowly added, and then the reaction mixture was gradually warmed to room temperature and left overnight. The reaction mixture was extracted twice with water and the aqueous phase was adjusted to pH 5 with concentrated hydrochloric acid. after acidification, the precipitate was collected by filtration to afford ethyl 4,6-dihydroxynicotinate (60.0 g, 60% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.99 (s, 1H), 5.58 (s, 1H), 4.23 (q, J = 6.8, 14.0 Hz, 2H), 1.25 (t, J = 7.2 Hz, 3H); MS (ESI) m/z: 184.1 [M + H]+.
References
[1] Patent: US8461179, 2013, B1. Location in patent: Page/Page column 66
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Suppliers
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- sales@advamacs.com
- Country
- Poland
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View Lastest Price from 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER manufacturers
- Product
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER 6975-44-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER 6975-44-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24