ACETOACETYL COENZYME A SODIUM SALT
- Product Name
- ACETOACETYL COENZYME A SODIUM SALT
- CAS No.
- 102029-52-7
- Chemical Name
- ACETOACETYL COENZYME A SODIUM SALT
- Synonyms
- Acetyl-CoA oxidase;Acetoacetyl coenzyme A;ACETOACETYL COENZYME A SODIUM;ACETOACETYL COENZYME A SODIUM SALT;S-(3-oxobutanoate)-CoA,tetrasodiumsalt;ACETOACETYL COENZYME A TRISODIUM SALT &;Acetoacetyl coenzyme A hydrate sodium salt;Acetoacetyl coenzyme A trisodium salt tetrahydrate;Coenzyme A,S-(3-oxobutanoate), tetrasodium salt (9CI);coenzyme A acetoacetyl derivative trisodium salt hydrate
- CBNumber
- CB0692964
- Molecular Formula
- C25H37N7Na3O18P3S
- Formula Weight
- 917.55
- MOL File
- 102029-52-7.mol
ACETOACETYL COENZYME A SODIUM SALT Property
- storage temp.
- −20°C
- solubility
- H2O: 50 mg/mL, clear, colorless to faintly yellow
Safety
- WGK Germany
- 3
- F
- 10-21
N-Bromosuccinimide Price
- Product number
- 235095
- Product name
- Acetoacetyl Coenzyme A, Trisodium Salt Tetrahydrate
- Packaging
- 5mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- NA47206
- Product name
- Acetoacetyl coenzyme A trisodium salt tetrahydrate
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- ENZ0008576
- Product name
- ACETOACETYL COENZYME A SODIUM SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $859.62
- Updated
- 2021/12/16
- Product number
- NA47206
- Product name
- Acetoacetyl coenzyme A trisodium salt tetrahydrate
- Packaging
- 50mg
- Price
- $2500
- Updated
- 2021/12/16
ACETOACETYL COENZYME A SODIUM SALT Chemical Properties,Usage,Production
Uses
Acetoacetyl coenzyme A sodium is a central endogenous metabolite. The Km at pH 7.5 for Acetoacetyl coenzyme A sodium is 1.10 mM. Acetoacetyl coenzyme A sodium can be used for the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB)[1][2].
IC 50
Microbial Metabolite
Purification Methods
Purification can be carried out by passage through a DEAE-cellulose formate column, then through a Dowex 50 (H+) column to remove Na ions, concentrated by lyophilisation and redissolved in H2O. It is commercially available as a solution of 0.05g/mL of H2O. The concentration of acetoacetylcoenzyme A is determined by the method of Stern et al. [J Biol Chem 221 15 1956]. It is stable at pH 7-7.5 for several hours at 0o (half-life ca 1-2hours). At room temperature it is hydrolysed in ca 1-2hours at pH 7-7.5. At pH 1.0/20o it is more stable than at neutrality. A solution of the trisodium salt (0.05g/mL H2O) adjusted to pH 5 with 2N NaOH can be stored frozen for several weeks. It is stable at pH 2-3/-17o for at least 6 months. [Hersch & Jencks J Biol Chem 242 3468 1967, Clikenbeard et al. J Biol Chem 250 3108 1975, Simon & Shemin J Am Chem Soc 75 2520 1953, Moffatt & Khorana 81 1265 1959, Salem et al. Biochem J 258 563 1989, Beilstein 26 III/IV 3668.]
References
[1] Thompson DK, et al. Purification and properties of an acetoacetyl coenzyme A-reacting phosphotransbutyrylase from Clostridium beijerinckii ("Clostridium butylicum") NRRL B593. Appl Environ Microbiol. 1990 Mar;56(3):607-13. DOI:10.1128/aem.56.3.607-613.1990
[2] Chohan SN, et al. Acetoacetyl coenzyme A reductase and polyhydroxybutyrate synthesis in rhizobium (Cicer) sp. Strain CC 1192. Appl Environ Microbiol. 1998 Aug;64(8):2859-63. DOI:10.1128/AEM.64.8.2859-2863.1998
ACETOACETYL COENZYME A SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
ACETOACETYL COENZYME A SODIUM SALT Suppliers
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- Switzerland
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