Y-27632 DIHYDROCHLORIDE

Product Name: Y-27632 DIHYDROCHLORIDE
CAS No.: 146986-50-7
Chemical Name: Y-27632 DIHYDROCHLORIDE
Synonyms: Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 (2HCl),98%;Y-27632, free base;Y-27632 dihydrochlor
CBNumber: CB0699488
Molecular Formula: C14H21N3O
Formula Weight: 247.34
MOL File: 146986-50-7.mol

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Y-27632 DIHYDROCHLORIDE Property

Melting point:: >260°C (dec.)
Boiling point:: 462.6±15.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: H₂O: 14 mg/mL
form: solid
pka: 13.53±0.40(Predicted)
color: white
Stability:: Hygroscopic

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.09228
Product name: InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem
Packaging: 2mg
Price: $378
Updated: 2024/03/01

Sigma-Aldrich

Product number: 688000
Product name: Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging: 1MG
Price: $238
Updated: 2023/01/07

Sigma-Aldrich

Product number: 688000
Product name: Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging: 5MG
Price: $894
Updated: 2023/01/07

Sigma-Aldrich

Product number: 688000
Product name: Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging: 10MG
Price: $1200
Updated: 2023/01/07

Sigma-Aldrich

Product number: 688000
Product name: Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging: 100MG
Price: $2170
Updated: 2023/01/07

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Y-27632 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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Y-27632 DIHYDROCHLORIDE Suppliers

China 130 Germany 3 Japan 2 Switzerland 2 United Kingdom 4 United States 25 Global 166

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View Lastest Price from Y-27632 DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: Y-27632 DIHYDROCHLORIDE 146986-50-7
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-07

146986-50-7, Y-27632 DIHYDROCHLORIDERelated Search:

Y-27632 (2HCl), 5 mg Y6 Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632 DIHYDROCHLORIDE 1,4-Cyclohexanebis(methylamine)

ROCK INHIBITOR

(R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL

(R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE

(+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O

Y-27632

Y-27632 DIHYDROCHLORIDE

TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE

Y-276322HCl

4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride

(1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride

CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans-

Y-27632/Y27632

Y-27632, Free Base, >99%

(+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide

Y-27632 (2HCl),98%

4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide

(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide

Y-27632, free base

4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide

4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide

(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride

CS-20

4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide

(+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide

(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide

Y-27632 dihydrochlor

Rock inhibitor y-27632

trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide

trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide , Y-27632

146986-50-7

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Rho Kinase (ROCK)

Serine/Threonine Kinase Inhibitors

Inhibitors

Protein Kinase

Signalling

Inhibitor

APIs

SiChem