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ChemicalBook > CAS DataBase List > Y-27632

Y-27632

Background
Product Name
Y-27632
CAS No.
146986-50-7
Chemical Name
Y-27632
Synonyms
Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 99.87%;Y-27632Y125330;Y-27632 (2HCl),98%
CBNumber
CB0699488
Molecular Formula
C14H21N3O
Formula Weight
247.34
MOL File
146986-50-7.mol
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Y-27632 Property

Melting point:
>260°C (dec.)
Boiling point:
462.6±15.0 °C(Predicted)
Density 
1.136±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
H2O: 14 mg/mL
form 
solid
pka
13.53±0.40(Predicted)
color 
white
Stability:
Hygroscopic
InChI
InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
InChIKey
IYOZTVGMEWJPKR-IJLUTSLNSA-N
SMILES
[C@@H]1(C(NC2C=CN=CC=2)=O)CC[C@@H]([C@H](N)C)CC1
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
Storage Class
12 - Non Combustible Liquids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
1MG
Price
$265
Updated
2025/07/31
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
5MG
Price
$948
Updated
2025/07/31
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
10MG
Price
$1270
Updated
2025/07/31
Sigma-Aldrich
Product number
688000
Product name
Y-27632 - CAS 146986-50-7 - Calbiochem
Packaging
100MG
Price
$2300
Updated
2025/07/31
Sigma-Aldrich
Product number
688001
Product name
Y-27632
Purity
InSolution, ≥95%, reversible, inhibitor of Rho kinases
Packaging
500μg
Price
$163
Updated
2025/07/31
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Y-27632 Chemical Properties,Usage,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

in vivo

Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group[3]. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)[4].

IC 50

ROCK-I: 220 nM (Ki); ROCK-II: 300 nM (Ki); PKN: 3.1 μM (Ki); Citron kinase: 5.3 μM (Ki); PKCα: 73 μM (Ki); PKA: 25 μM (Ki)

Background

Y-27632 is a potent and selective ATP-competitive inhibitor of Rho-associated kinases, with Ki values of 0.22 µM and 0.30 µM for ROCK1 and ROCK2, respectively. In vitro kinase assays demonstrate that Y-27632 exhibits a 20-fold greater preference for ROCK when compared to citron kinase and protein kinase N. Research studies show that Y-27632 treatment of cells leads to inhibition of ROCK phosphorylation of myosin phosphatase subunit 1 at both Thr853 and Thr696, with a much greater inhibition of Thr853 phosphorylation. Y-27632 selectively inhibits smooth-muscle contraction by inhibiting Ca2+ sensitization. Additional research indicates that Y-27632 inhibits dissociation-induced apoptosis of cultured human embryonic stem cells over numerous passages and increases cloning efficiency.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 Preparation Products And Raw materials

Raw materials

Preparation Products

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Y-27632 Suppliers

China 236 Germany 3 Japan 2 Switzerland 2 United Kingdom 4 United States 26 Global 273
Suzhou MgPlus Pharmtech Co., Ltd.
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0512-66727658 18115508618
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phoenix888.ok@163.com
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China
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Changsha Hanchen Biotechnology Co., LTD
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18175992585
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luohuichao@hanchbio.cn
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China
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Changzhou Yongfeng Biomedicine Co. Ltd.
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15006117673
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2973592490@.com
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2973592490@qq.com
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China
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299
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.
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13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
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China
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
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sales@boylechem.com
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China
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2922
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
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United Kingdom
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VDM Biochemicals
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0330-2528181
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0330-2528171
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sales@vdmbio.com
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United States
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View Lastest Price from Y-27632 manufacturers

Career Henan Chemical Co
Product
Y-27632 DIHYDROCHLORIDE 146986-50-7
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-07

146986-50-7, Y-27632Related Search:

Y-27632 (2HCl), 5 mg Y6 N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Y-27632 dihydrochloride (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632 1,4-Cyclohexanebis(methylamine)

  • ROCK INHIBITOR
  • (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL
  • (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
  • (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O
  • Y-27632
  • TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
  • Y-276322HCl
  • 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride
  • (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride
  • CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans-
  • Y-27632/Y27632
  • Y-27632, Free Base, >99%
  • (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide
  • Y-27632 (2HCl),98%
  • 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide
  • (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
  • Y-27632, free base
  • 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide
  • 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
  • (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride
  • CS-20
  • 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide
  • (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide
  • (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide
  • Y-27632 dihydrochlor
  • Rock inhibitor y-27632
  • trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
  • trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide , Y-27632
  • Y-27632, 10 mM in DMSO
  • Y-27632 99.87%
  • Y-27632Y125330
  • 146986-50-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Rho Kinase (ROCK)
  • Serine/Threonine Kinase Inhibitors
  • Inhibitors
  • Protein Kinase
  • Signalling
  • Inhibitor
  • APIs
  • SiChem