2,6-DICHLORO-9-METHYL-9H-PURINE

Product Name: 2,6-DICHLORO-9-METHYL-9H-PURINE
CAS No.: 2382-10-7
Chemical Name: 2,6-DICHLORO-9-METHYL-9H-PURINE
Synonyms: 2,6-Dichloro-9-Methylpurine;9-Methyl-2,6-dichloropurine;2,6-DICHLORO-9-METHYL-9H-PURINE;2,6-dichloro-9-methyl-1H-purine;9H-Purine, 2,6-dichloro-9-methyl-;2,6-dichloro-9-methyl-9H-purine176328;Hexanoicacid,5-methyl-5-oxo-,ethylester
CBNumber: CB0766720
Molecular Formula: C6H4Cl2N4
Formula Weight: 203.03
MOL File: Mol file

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2,6-DICHLORO-9-METHYL-9H-PURINE Property

Melting point:: 152-153℃
Boiling point:: 307.2±52.0 °C(Predicted)
Density: 1.76
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.90±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C6H4Cl2N4/c1-12-2-9-3-4(7)10-6(8)11-5(3)12/h2H,1H3
InChIKey: HWMJNDVUIMQFEW-UHFFFAOYSA-N
SMILES: N1C2C(=NC(Cl)=NC=2Cl)N(C)C=1
CAS DataBase Reference: 2382-10-7

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: D435235
Product name: 2,6-DICHLORO-9-METHYLPURINE
Packaging: 10g
Price: $1240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0320727
Product name: 2,6-DICHLORO-9-METHYL-9H-PURINE
Purity: 95.00%
Packaging: 5MG
Price: $505.68
Updated: 2021/12/16

AK Scientific

Product number: J50362
Product name: 2,6-Dichloro-9-methyl-9H-purine
Packaging: 25g
Price: $520
Updated: 2021/12/16

Matrix Scientific

Product number: 119432
Product name: 2,6-Dichloro-9-methyl-9H-purine
Purity: 95+%
Packaging: 1g
Price: $132
Updated: 2021/12/16

Matrix Scientific

Product number: 119432
Product name: 2,6-Dichloro-9-methyl-9H-purine
Purity: 95+%
Packaging: 5g
Price: $395
Updated: 2021/12/16

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2,6-DICHLORO-9-METHYL-9H-PURINE Chemical Properties,Usage,Production

Uses

2,6-DICHLORO-9-METHYLPURINE acts as a reagent in the synthesis of highly selective inhibitors of PI3K-δ used in the treatment of inflammatory diseases such as leukocyte related illnesses.

Synthesis

5451-40-1

74-88-4

2382-10-7

Procedure for the synthesis of 2,6-dichloro-9-methyl-9H-purine (15b): potassium carbonate (K2CO3, 0.270 g, 1.95 mmol) was added to an anhydrous DMF (1.0 mL) solution of 2,6-dichloro-9H-purine (0.120 g, 0.635 mmol) at 0°C followed by the addition of iodomethane (0.20 mL, 3.21 mmol). The reaction mixture was stirred continuously at 0 °C for 5 hours. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), concentrated and purified by silica gel (SiO2) column chromatography with an elution gradient from 100% hexane to 100% ethyl acetate (EtOAc) to afford the target product 15b (83.0 mg, 0.409 mmol, 64% yield) as a colorless solid. The product characterization data were as follows: IR (ATR, neat) 3067, 1554, 1360, 1333, 1223, 1147 cm-1; 1H NMR (CDCl3, 600 MHz) δ 8.09 (s, 1H), 3.89 (s, 3H); 13C NMR (CDCl3, 150 MHz) δ 153.3, 152.7, 151.3, 146.4, 130.4, 30.4.

References

[1] Patent: WO2014/189830, 2014, A1. Location in patent: Page/Page column 35
[2] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 12, p. 985 - 990
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 12, p. 3486 - 3490
[4] Patent: US2011/237607, 2011, A1. Location in patent: Page/Page column 6; 7
[5] Patent: WO2016/91916, 2016, A1. Location in patent: Page/Page column 66

2,6-DICHLORO-9-METHYL-9H-PURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DICHLORO-9-METHYL-9H-PURINE Suppliers

China 73 India 2 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 9 Global 88

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2382-10-7, 2,6-DICHLORO-9-METHYL-9H-PURINERelated Search:

Purine

2,6-DICHLORO-9-METHYL-9H-PURINE

9-Methyl-2,6-dichloropurine

2,6-dichloro-9-methyl-9H-purine176328

2,6-Dichloro-9-Methylpurine

9H-Purine, 2,6-dichloro-9-methyl-

2,6-dichloro-9-methyl-1H-purine

Hexanoicacid,5-methyl-5-oxo-,ethylester

2382-10-7

2832-10-7