1,4-DIBROMOISOQUINOLINE
- Product Name
- 1,4-DIBROMOISOQUINOLINE
- CAS No.
- 51206-40-7
- Chemical Name
- 1,4-DIBROMOISOQUINOLINE
- Synonyms
- 1,4-DIBROMOISOQUINOLINE;Isoquinoline, 1,4-dibromo-;1,4-DIBROMOISOQUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB0769271
- Molecular Formula
- C9H5Br2N
- Formula Weight
- 286.95
- MOL File
- 51206-40-7.mol
1,4-DIBROMOISOQUINOLINE Property
- Boiling point:
- 352.5±22.0 °C(Predicted)
- Density
- 1.923
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.02±0.31(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D425538
- Product name
- 1,4-Dibromoisoquinoline
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 072377
- Product name
- 1,4-Dibromoisoquinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $537
- Updated
- 2021/12/16
- Product number
- W6621
- Product name
- 1,4-Dibromoisoquinoline
- Packaging
- 10g
- Price
- $1011
- Updated
- 2021/12/16
- Product number
- 072377
- Product name
- 1,4-Dibromoisoquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1158
- Updated
- 2021/12/16
- Product number
- HCH0069282
- Product name
- 1,4-DIBROMO-ISOQUINOLINE
- Purity
- 96.00%
- Packaging
- 250MG
- Price
- $1167.71
- Updated
- 2021/12/16
1,4-DIBROMOISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
491-30-5
51206-40-7
General procedure for the synthesis of 1,4-dibromoisoquinoline from 1-hydroxyisoquinoline: 2.90 g (19.07 mmol) of 1-hydroxyisoquinoline was mixed with 14.40 g (33.68 mmol) of phosphorus pentabromide and heated to a molten state at 140 °C. The reaction was carried out at a temperature of about 2.5 ° C. The reaction was carried out in the presence of a red liquid. During the reaction, the melt gradually transformed into a red liquid and after about 10 minutes, the reaction mixture solidified and subsequently cooled to room temperature. The solidified reaction mixture was pulverized and slowly poured into ice water. The resulting solid product was collected by filtration and dried in air. 5.50 g of 1,4-dibromoisoquinoline was finally obtained in 96% yield with a melting point of 94-96 °C. The product had an Rf value of 0.66 in a hexane solution of 40% ethyl acetate.
References
[1] Patent: EP1228063, 2009, B1. Location in patent: Page/Page column 32
[2] Patent: WO2007/118602, 2007, A1. Location in patent: Page/Page column 51
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 8029 - 8047
[4] Patent: WO2017/103586, 2017, A1. Location in patent: Page/Page column 38
[5] Patent: US2010/222345, 2010, A1. Location in patent: Page/Page column 97
1,4-DIBROMOISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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