(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

Product Name: (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
CAS No.: 354811-10-2
Chemical Name: (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
Synonyms: IKK2-IN-4;IKK-2 INHIBITOR VI;IKK2 Inhibitor VI,IKK-2 Inhibitor VI;(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide;2-(carbamoylamino)-5-phenylthiophene-3-carboxamide;2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide;3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV
CBNumber: CB0789277
Molecular Formula: C12H11N3O2S
Formula Weight: 261.3
MOL File: Mol file

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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Property

Melting point:: >210°C (dec.)
Boiling point:: 445.6±45.0 °C(Predicted)
Density: 1.426±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO, Methanol (Slightly)
pka: 14.00±0.70(Predicted)
form: Solid
color: Light Beige to Light Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17276
Product name: IKK2 Inhibitor VI
Purity: ≥95%
Packaging: 500μg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 17276
Product name: IKK2 Inhibitor VI
Purity: ≥95%
Packaging: 1mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 17276
Product name: IKK2 Inhibitor VI
Purity: ≥95%
Packaging: 5mg
Price: $480
Updated: 2024/03/01

TRC

Product number: P338250
Product name: (5-Phenyl-2-ureido)thiophene-3-carboxamide
Packaging: 2.5mg
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: 8102CP
Product name: 5-Phenyl-2-Ureidothiophene-3-Carboxamide
Packaging: 5mg
Price: $633
Updated: 2021/12/16

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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Chemical Properties,Usage,Production

Description

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC₅₀ = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.

Uses

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE is an inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.

Uses

An ureido-thiophenecarboxamide compound that acts as a potent inhibitor of IKK-2 (InhibitorVI).

IC 50

IKK-2: 25 nM (IC₅₀)

References

[1] ANDREW BAXTER et al. et al. Hit-to-Lead Studies: The Discovery of Potent, Orally Active, Thiophenecarboxamide IKK-2 Inhibitors.[J]. ChemInform, 2004, 35 39. DOI: 10.1002/chin.200439220
[2] LUCY A MCNAMARA Kathleen L C Janani A Ganesh. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.[J]. Journal of Virology, 2012: 9337-9350. DOI: 10.1128/jvi.00895-12
[3] VASU PUNJ Preet M C Hittu Matta. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma.[J]. PLoS ONE, 2012: e37498. DOI: 10.1371/journal.pone.0037498

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Suppliers

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354811-10-2, (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDERelated Search:

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

IKK-2 INHIBITOR VI

2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide

2-(carbamoylamino)-5-phenylthiophene-3-carboxamide

3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-

5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

IKK2 Inhibitor VI,IKK-2 Inhibitor VI

5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV

IKK2-IN-4

354811-10-2

Aromatics Compounds

Aromatics

Inhibitors

Sulfur & Selenium Compounds

An ureido-thiophenecarboxamide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 13 nM).