ChemicalBook > CAS DataBase List > BRD-K98645985

BRD-K98645985

Product Name
BRD-K98645985
CAS No.
1357647-78-9
Chemical Name
BRD-K98645985
Synonyms
BRD-K98645985;BRD K98645985,BRD-K-98645985,BRDK98645985;Urea, N-(1-methylethyl)-N'-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-
CBNumber
CB08024433
Molecular Formula
C33H43N5O4
Formula Weight
573.73
MOL File
1357647-78-9.mol
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BRD-K98645985 Property

Boiling point:
699.4±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
13.73±0.46(Predicted)
form 
Solid
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0080982
Product name
BRD-K98645985
Purity
99.19%
Packaging
1mg
Price
$1700
Updated
2021/12/16
ChemScene
Product number
CS-0080982
Product name
BRD-K98645985
Purity
99.19%
Packaging
5mg
Price
$6500
Updated
2021/12/16
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BRD-K98645985 Chemical Properties,Usage,Production

Definition

ChEBI: 1-[(4S,7S,8R)-8-methoxy-4,7,10-trimethyl-11-oxo-5-[[4-(2-pyridinyl)phenyl]methyl]-2-oxa-5,10-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-propan-2-ylurea is an azamacrocycle and a lactam.

Biological Activity

BRD-K98645985 is an inhibitor of BAF (mammalian SWI/SNF) transcriptional repression with EC50 of ~2.37 μM. It binds ARID1A-specific BAF complexes, prevents nucleosome localization, and potently reverses HIV-1 latency without T cell toxicity.

in vitro

BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1 , 2.6-fold increase in Ring1 , and 3.3- fold decrease in Fgf4 .
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting.

target

BAF transcriptional repression

< span> 2.37 μM (EC 50 )

HIV-1

BRD-K98645985 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRD-K98645985 Suppliers

China 29 United States 4 Global 33
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
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12952
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32436
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
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4990
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cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
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China
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10503
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Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3000
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58

1357647-78-9, BRD-K98645985Related Search:


  • BRD-K98645985
  • BRD K98645985,BRD-K-98645985,BRDK98645985
  • Urea, N-(1-methylethyl)-N'-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-
  • 1357647-78-9