SBi4211 dimethanesulfonate

Product Name: SBi4211 dimethanesulfonate
CAS No.: 161374-55-6
Chemical Name: SBi4211 dimethanesulfonate
Synonyms: SBi4211 dimethanesulfonate;Heptamidine dimethanesulfote;Heptamidine dimethanesulfonate;Heptamidine dimethanesulfonate, 10 mM in DMSO;4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate;Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell
CBNumber: CB08054427
Molecular Formula: C22H32N4O5S
Formula Weight: 464.58
MOL File: 161374-55-6.mol

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SBi4211 dimethanesulfonate Property

storage temp.: Store at -20°C
solubility: DMSO: 62.5 mg/mL (111.47 mM)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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SBi4211 dimethanesulfonate Chemical Properties,Usage,Production

Uses

Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].

in vivo

Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in?HSALR?mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg^[2].

Animal Model:	Homozygous?HSALR?transgenic mice in line 20b (FVB inbred background)?with a Myotonic dystrophy (DM) mouse model^[2]
Dosage:	20 or 30 mg/kg
Administration:	Intraperitoneal injection; 7 days; once daily
Result:	Reversed splicing defects and rescues myotonia in a DM mouse model.

References

[1] McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett.?2012?Dec 13;3(12):975-979. Epub?2012?Sep 25. DOI:10.1021/ml300166s
[2] Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol.?2013 Nov 15;8(11):2528-37. DOI:10.1021/cb400431f

SBi4211 dimethanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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161374-55-6, SBi4211 dimethanesulfonateRelated Search:

Heptamidine dimethanesulfonate

Heptamidine dimethanesulfote

SBi4211 dimethanesulfonate

4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate

Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell

Heptamidine dimethanesulfonate, 10 mM in DMSO

161374-55-6