SBi4211 dimethanesulfonate
- Product Name
- SBi4211 dimethanesulfonate
- CAS No.
- 161374-55-6
- Chemical Name
- SBi4211 dimethanesulfonate
- Synonyms
- SBi4211 dimethanesulfonate;Heptamidine dimethanesulfote;Heptamidine dimethanesulfonate;Heptamidine dimethanesulfonate, 10 mM in DMSO;4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate;Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell
- CBNumber
- CB08054427
- Molecular Formula
- C22H32N4O5S
- Formula Weight
- 464.58
- MOL File
- 161374-55-6.mol
SBi4211 dimethanesulfonate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (111.47 mM)
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
SBi4211 dimethanesulfonate Chemical Properties,Usage,Production
Uses
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
in vivo
Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in?HSALR?mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg[2].
| Animal Model: | Homozygous?HSALR?transgenic mice in line 20b (FVB inbred background)?with a Myotonic dystrophy (DM) mouse model[2] |
| Dosage: | 20 or 30 mg/kg |
| Administration: | Intraperitoneal injection; 7 days; once daily |
| Result: | Reversed splicing defects and rescues myotonia in a DM mouse model. |
References
[1] McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett.?2012?Dec 13;3(12):975-979. Epub?2012?Sep 25. DOI:10.1021/ml300166s
[2] Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol.?2013 Nov 15;8(11):2528-37. DOI:10.1021/cb400431f
SBi4211 dimethanesulfonate Preparation Products And Raw materials
Raw materials
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