ChemicalBook > CAS DataBase List > 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

Product Name
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
CAS No.
2226664-93-1
Chemical Name
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
Synonyms
A3051;Ky19382;KY19382（A3051）;KY19382 (A3051) ，S6085;KY19382, 10 mM in DMSO;5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382;Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3
CBNumber
CB08094272
Molecular Formula
C17H11Cl2N3O2
Formula Weight
360.19
MOL File
2226664-93-1.mol
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2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Property

Density 
1.58±0.1 g/cm3(Predicted)
solubility 
DMSO: Soluble
pka
8.80±0.20(Predicted)
form 
Solid
color 
Brown to reddish brown
InChI
InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23)
InChIKey
PROTUMHDKVZVBW-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Cl)C(Cl)=C2)C(=C2C(=NOC)C3=C(N2)C=CC=C3)C1=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0134890
Product name
KY19382
Purity
98.04%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0134890
Product name
KY19382
Purity
98.04%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0134890
Product name
KY19382
Purity
98.04%
Packaging
50mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0134890
Product name
KY19382
Purity
98.04%
Packaging
100mg
Price
$2900
Updated
2021/12/16
DC Chemicals
Product number
DC40570
Product name
KY19382
Purity
>98%
Packaging
100mg
Price
$750
Updated
2021/12/16
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2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Chemical Properties,Usage,Production

Uses

KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β.

in vivo

KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng?h/ml[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2].

Animal Model:C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1]
Dosage:0.1 mg/kg
Administration:I.p. once daily for 2 weeks
Result:Increased nuclear β-catenin in the growth plate chondrocytes dramatically.
Elevated the height of each growth plate zone and BrdU-positive cells.
Did not affect the cartilage resorption of rapidly growing young mice.
Animal Model:SD male rats[1]
Dosage:1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis)
Administration:I.v. and i.p. administration
Result:I.v.: t1/2=3.33 h; AUC=7832.81 ng?h/mL; CL=0.12 L/h/kg.
I.p.: t1/2=16.20 h; F=16.74%; Cmax=463.37 ng/mL.

IC 50

CXXC5-DVL: 19 nM (IC50); GSK3β: 10 nM (IC50)

References

[1] SEHEE CHOI. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.[J]. Life Science Alliance, 2019. DOI: 10.26508/lsa.201800254

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Suppliers

China 34 United States 4 Global 38
DC Chemicals
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InvivoChem
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sales@invivochem.cn
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TargetMol Chemicals Inc.
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View Lastest Price from 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
Ky19382 2226664-93-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99% min
Supply Ability
20 tons
Release date
2025-12-08
Shaanxi Dideu New Materials Co. Ltd
Product
KY19382 2226664-93-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-12-01

2226664-93-1, 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Related Search:


  • 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
  • Ky19382
  • A3051
  • 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382
  • Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3
  • 5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one
  • KY19382（A3051）
  • KY19382, 10 mM in DMSO
  • KY19382 (A3051) ，S6085
  • 2226664-93-1