ChemicalBook > CAS DataBase List > 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

Product Name
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
CAS No.
1453099-83-6
Chemical Name
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
Synonyms
TAS-119;TAS2104;TAS 2104;VIC-1911;TAS-2104;VIC-1911 (TAS-119);TAS-119, 10 mM in DMSO;TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119;4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
CBNumber
CB08101561
Molecular Formula
C23H22Cl2FN5O3
Formula Weight
506.36
MOL File
1453099-83-6.mol
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Property

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (98.74 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
25mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0138153
Product name
TAS-119
Purity
98.27%
Packaging
100mg
Price
$3400
Updated
2021/12/16
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Chemical Properties,Usage,Production

Uses

TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1].

in vivo

TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts[1].

Animal Model:Nude rats injected with HeLa-luc cells[1]
Dosage:5 mg/kg, 10 mg/kg, and 30 mg/kg
Administration:Oral administration; twice daily on day 1 and everyday on day 2
Result:Induced pHH3 at all doses in nude rats with the HeLa-luc xenografts.

IC 50

Aurora A: 1 nM (IC50); Aurora B: 95 nM (IC50)

References

[1] Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19(10):1981-1991. DOI:10.1158/1535-7163.MCT-20-0036

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Suppliers

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1453099-83-6, 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-Related Search:


  • 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
  • TAS-119
  • TAS 2104
  • TAS2104
  • TAS-2104
  • VIC-1911 (TAS-119)
  • TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119
  • TAS-119, 10 mM in DMSO
  • VIC-1911
  • 1453099-83-6
  • C23H22Cl2FN5O3
  • APIs