ChemicalBook > CAS DataBase List > 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
- Product Name
- 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
- CAS No.
- 1453099-83-6
- Chemical Name
- 4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
- Synonyms
- TAS-119;TAS2104;TAS 2104;VIC-1911;TAS-2104;VIC-1911 (TAS-119);TAS-119, 10 mM in DMSO;TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119;4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
- CBNumber
- CB08101561
- Molecular Formula
- C23H22Cl2FN5O3
- Formula Weight
- 506.36
- MOL File
- 1453099-83-6.mol
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (98.74 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0138153
- Product name
- TAS-119
- Purity
- 98.27%
- Packaging
- 5mg
- Price
- $400
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0138153
- Product name
- TAS-119
- Purity
- 98.27%
- Packaging
- 10mg
- Price
- $680
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0138153
- Product name
- TAS-119
- Purity
- 98.27%
- Packaging
- 25mg
- Price
- $1350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0138153
- Product name
- TAS-119
- Purity
- 98.27%
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0138153
- Product name
- TAS-119
- Purity
- 98.27%
- Packaging
- 100mg
- Price
- $3400
- Updated
- 2021/12/16
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Chemical Properties,Usage,Production
Uses
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1].
in vivo
TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts[1].
| Animal Model: | Nude rats injected with HeLa-luc cells[1] |
| Dosage: | 5 mg/kg, 10 mg/kg, and 30 mg/kg |
| Administration: | Oral administration; twice daily on day 1 and everyday on day 2 |
| Result: | Induced pHH3 at all doses in nude rats with the HeLa-luc xenografts. |
IC 50
Aurora A: 1 nM (IC50); Aurora B: 95 nM (IC50)
References
[1] Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19(10):1981-1991. DOI:10.1158/1535-7163.MCT-20-0036
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Suppliers
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
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