ChemicalBook > CAS DataBase List > 1-(4-amino-3-fluorophenyl)ethan-1-one

1-(4-amino-3-fluorophenyl)ethan-1-one

Product Name
1-(4-amino-3-fluorophenyl)ethan-1-one
CAS No.
73792-22-0
Chemical Name
1-(4-amino-3-fluorophenyl)ethan-1-one
Synonyms
4-Acetyl-2-fluoroaniline;3-Fluoro-4-aminoacetophenone;4’-Amino-3’-fluoroacetophenone;4'-Amino-3'-fluoroacetophenone;1-(4-Amino-3-fluorophenyl)ethanone;1-(4-amino-3-fluorophenyl)ethan-1-one;Ethanone, 1-(4-amino-3-fluorophenyl)-;Ethanone, 1-(4-amino-3-fluorophenyl)- (9CI)
CBNumber
CB0883289
Molecular Formula
C8H8FNO
Formula Weight
153.15
MOL File
73792-22-0.mol
More
Less

1-(4-amino-3-fluorophenyl)ethan-1-one Property

Melting point:
86-88℃
Boiling point:
286℃
Density 
1.201
Flash point:
127℃
storage temp. 
2-8°C(protect from light)
pka
0.77±0.10(Predicted)
Appearance
Light yellow to brown Solid
More
Less

Safety

HS Code 
2914790090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
A609785
Product name
1-(4-Amino-3-fluorophenyl)ethanone
Packaging
1g
Price
$70
Updated
2021/12/16
TRC
Product number
A609785
Product name
1-(4-Amino-3-fluorophenyl)ethanone
Packaging
10g
Price
$250
Updated
2021/12/16
TRC
Product number
A609785
Product name
1-(4-Amino-3-fluorophenyl)ethanone
Packaging
100g
Price
$1570
Updated
2021/12/16
AK Scientific
Product number
X8376
Product name
4'-Amino-3'-fluoroacetophenone
Packaging
1g
Price
$84
Updated
2021/12/16
AK Scientific
Product number
X8376
Product name
4'-Amino-3'-fluoroacetophenone
Packaging
5g
Price
$127
Updated
2021/12/16
More
Less

1-(4-amino-3-fluorophenyl)ethan-1-one Chemical Properties,Usage,Production

Uses

1-(4-Amino-3-fluorophenyl)ethanone can be used as a starting material in the preparation of 2-Amino-5-[(cyclopentylamino)acetyl]-3-fluoro-benzonitrile.

Synthesis

111-34-2

29632-74-4

73792-22-0

Example 7: Synthesis of (R)-N-(4-{1-[3-(4-tert-butyl-benzyl)-ureido]-ethyl}-2-fluoro-6-vinyl-phenyl)-methanesulfonamide; Step i: Preparation of 1-(4-amino-3-fluorophenyl)ethanone. In a 25 mL two-necked round-bottomed flask, filled with argon protection, a DMF solution of 2-fluoro-4-iodoaniline (1500 mg, 6.33 mmol) was added. Palladium(II) acetate (42.62 mg, 0.19 mmol), 1,3-bis(diphenylphosphino)propane (156.65 mg, 0.38 mmol, 0.06 equiv.), thallium(I) acetate (1834.19 mg, 6.96 mmol), and butyl vinyl ether (1.64 mL, 12.66 mmol, 2 equiv.) were then added sequentially. The reaction mixture was heated and stirred for 15 hours. After the reaction was completed, the mixture was poured into THF and 10% HCl solution was added slowly. The reaction mixture was extracted with ethyl acetate (300 mL x 3) and the organic phases were combined and washed sequentially with water and brine. The organic layer was dried with anhydrous Na2SO4, filtered and purified by column chromatography (n-hexane: ethyl acetate=3:1) to give a light yellow solid product (343.0 mg, yield 35.40%). Melting point: 77-79°C; IR (KBr pressed sheet, cm^-1): 3373, 3326, 1663, 1296; 1H NMR (400 MHz, CDCl3): δ 7.53 (m, 2H), 6.69 (m, 1H), 3.41 (s, 2H), 2.43 (s, 3H).

References

[1] Patent: WO2006/101318, 2006, A1. Location in patent: Page/Page column 44; 83-84
[2] Patent: EP1862454, 2007, A1. Location in patent: Page/Page column 6; 18

1-(4-amino-3-fluorophenyl)ethan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(4-amino-3-fluorophenyl)ethan-1-one Suppliers

China 62 Europe 1 India 1 Switzerland 1 United States 7 Global 72
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Changzhou Tianrui Pharmaceutical Technology Co., Ltd.
Tel
0519-85386832 13382812559
Fax
0519-85386832
Email
sales@cztrchem.com
Country
China
ProdList
1185
Advantage
56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
More
Less

View Lastest Price from 1-(4-amino-3-fluorophenyl)ethan-1-one manufacturers

Career Henan Chemical Co
Product
1-(4-amino-3-fluorophenyl)ethan-1-one 73792-22-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

73792-22-0, 1-(4-amino-3-fluorophenyl)ethan-1-oneRelated Search:

1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE 1-(4-aMino-3-iodophenyl)ethanone 1-(4-Amino-3-chloro-phenyl)-ethanone

  • 1-(4-amino-3-fluorophenyl)ethan-1-one
  • Ethanone, 1-(4-amino-3-fluorophenyl)- (9CI)
  • 1-(4-Amino-3-fluorophenyl)ethanone
  • 4'-Amino-3'-fluoroacetophenone
  • 3-Fluoro-4-aminoacetophenone
  • 4-Acetyl-2-fluoroaniline
  • Ethanone, 1-(4-amino-3-fluorophenyl)-
  • 4’-Amino-3’-fluoroacetophenone
  • 73792-22-0
  • Fluorine series
  • ACETYLGROUP