(S)-3-N-Boc-3-(methylamino)piperidine
- Product Name
- (S)-3-N-Boc-3-(methylamino)piperidine
- CAS No.
- 309962-63-8
- Chemical Name
- (S)-3-N-Boc-3-(methylamino)piperidine
- Synonyms
- S-3-N-Boc-3-(Methylamino)piperdine;(S)-3-Boc-3-(Methylamino)piperidine;(S)-3-(N-Boc-MethylaMino)piperidine;(S)-N-Boc-N-methylpiperidin-3-amine;(S)-3-N-Boc-3-(methylamino)piperidine;(S)-tert-butyl piperidin-3-ylMethylcarbaMate;(S)-TERT-BUTYLMETHYL(PIPERIDIN-3-YL)CARBAMATE;tert-butyl (S)-methyl(piperidin-3-yl)carbamate;(S)-3-N-Boc-3-(MethylaMino)piperidine, ee: 98%;tert-butyl Methyl[(3S)-piperidin-3-yl]carbaMate
- CBNumber
- CB0948009
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 309962-63-8.mol
(S)-3-N-Boc-3-(methylamino)piperidine Property
- Boiling point:
- 288℃
- Density
- 1.01
- Flash point:
- 128℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 9.74±0.10(Predicted)
- Appearance
- Colorless to light yellow Viscous liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809743
- Product name
- (S)-tert-ButylMethyl(piperidin-3-yl)carbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB154100
- Product name
- (S)-3-N-Boc-3-(Methylamino)piperidine
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- AS3007
- Product name
- (S)-tert-butyl Methyl(piperidin-3-yl)carbamate
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 073457
- Product name
- (S)-tert-Butyl methyl(piperidin-3-yl)carbamate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- FB154100
- Product name
- (S)-3-N-Boc-3-(Methylamino)piperidine
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
(S)-3-N-Boc-3-(methylamino)piperidine Chemical Properties,Usage,Production
Chemical Properties
Light yellow viscid liquid
Uses
(S)-tert-Butyl methyl(piperidin-3-yl)carbamate is a useful reactant for the synthesis substituted azoles, thiophenes and furans that act as sterol regulatory element-?binding proteins (SREBPs) inhibitors.
Synthesis
309962-62-7
74-88-4
309962-63-8
The product of Example 42A (1.78 g, 6.0 mmol) was dissolved in THF (30 mL) at 0 °C and NaH (0.360 g, 60% dispersion, 9.0 mmol) was added. After stirring for 20 min, iodomethane (1.12 mL, 18 mmol) was added dropwise to the mixture, followed by slow warming of the reaction system to room temperature. After continued stirring for 4 hours, methanol (5 mL) was slowly added to quench the reaction, followed by concentration of the reaction mixture under reduced pressure. The concentrated residue was dissolved in fresh methanol (50 mL) and 20% aqueous K2CO3 (5 mL) was added. After stirring at room temperature for 16 hours, the mixture was concentrated under reduced pressure. The residue was extracted by partitioning with dichloromethane (50 mL) and saturated saline (20 mL). The organic phase was separated, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol/ammonia, 95:5:0.5, v/v/v) to afford the title compound (S)-3-N-BOC-3-(methylamino)piperidine as a hygroscopic yellow solid (1.14 g, 93% yield). Mass spectrum (chemical ionization/NH3) m/z 215 ([M+H]+).
References
[1] Patent: EP1428824, 2004, A1. Location in patent: Page 45
(S)-3-N-Boc-3-(methylamino)piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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