ChemicalBook > CAS DataBase List > 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
- Product Name
- 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
- CAS No.
- 141286-78-4
- Chemical Name
- 2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E
- Synonyms
- PEPA,inhibit,Inhibitor,iGluR,Ionotropic glutamate receptors;2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide;Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-;2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA)
- CBNumber
- CB0972925
- Molecular Formula
- C16H16F2N2O4S2
- Formula Weight
- 402.44
- MOL File
- 141286-78-4.mol
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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Property
- Boiling point:
- 617.6±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- protect from light
- solubility
- DMSO: >20mg/mL
- form
- solid
- pka
- 10.44±0.40(Predicted)
- color
- white
- InChIKey
- GTACSIONMHMRPD-UHFFFAOYSA-N
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D8941
- Product name
- 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- D8941
- Product name
- 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $728
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29190
- Product name
- PEPA
- Packaging
- 5mg
- Price
- $88
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29190
- Product name
- PEPA
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
TRC
- Product number
- P999023
- Product name
- PEPA
- Packaging
- 25mg
- Price
- $190
- Updated
- 2021/12/16
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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Chemical Properties,Usage,Production
Uses
PEPA is an allosteric potentiator of AMPA desensitization.
Biological Activity
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Biochem/physiol Actions
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Preparation Products And Raw materials
Raw materials
Preparation Products
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2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E Suppliers
- Tel
- --
- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
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