ChemicalBook > CAS DataBase List > (S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide

(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide

Product Name
(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide
CAS No.
2632342-05-1
Chemical Name
(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide
Synonyms
MC-Gly-Gly-Phe-Gly-PAB;Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) (HPLC >95%);6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[4-(hydroxymethyl)anilino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide;(S)-6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[2-[[2-[[1-[[2-[[4-(hydroxymethyl)phenyl]amino]-2-oxoethyl]amino]-1-oxo-3-phenyl-2-propyl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide;(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide
CBNumber
CB09755639
Molecular Formula
C32H38N6O8
Formula Weight
634.68
MOL File
2632342-05-1.mol
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(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide Property

Boiling point:
1108.4±65.0 °C(Predicted)
Density 
1.328±0.06 g/cm3(Predicted)
storage temp. 
-80°C, 2 years; -20°C, 1 year (Sealed storage, away from moisture)
form 
Solid
pka
13.34±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide Chemical Properties,Usage,Production

Uses

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

IC 50

Cleavable Linker

(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide Suppliers

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2632342-05-1, (S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamideRelated Search:


  • MC-Gly-Gly-Phe-Gly-PAB
  • (S)-6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-((1-((2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)hexanamide
  • Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) (HPLC >95%)
  • (S)-6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[2-[[2-[[1-[[2-[[4-(hydroxymethyl)phenyl]amino]-2-oxoethyl]amino]-1-oxo-3-phenyl-2-propyl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide
  • 6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[4-(hydroxymethyl)anilino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide
  • 2632342-05-1
  • C32H38N6O8