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IL-1R Antagonist

Product Name
IL-1R Antagonist
CAS No.
566914-00-9
Chemical Name
IL-1R Antagonist
Synonyms
IL-1R Antagonist;TLR1, 10 mM in DMSO;IL-1R antagonist(TLR1);I912552 IL-1R Antagonist,98%;TLR1,TLR-1,TLR 1,Inhibitor,MyD88,inhibit;Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]-;Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-;N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide;(S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide
CBNumber
CB11038456
Molecular Formula
C18H26N2O2
Formula Weight
302.41
MOL File
566914-00-9.mol
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IL-1R Antagonist Property

storage temp. 
2-8°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21349
Product name
IL-1R Antagonist
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
21349
Product name
IL-1R Antagonist
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
21349
Product name
IL-1R Antagonist
Purity
≥98%
Packaging
10mg
Price
$100
Updated
2024/03/01
Biosynth Carbosynth
Product number
BA163771
Product name
IL-1R Antagonist
Packaging
500ug
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
BA163771
Product name
IL-1R Antagonist
Packaging
1mg
Price
$150
Updated
2021/12/16
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IL-1R Antagonist Chemical Properties,Usage,Production

Uses

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].

Biological Activity

Cell permeable: yes', 'Primary Target
TIR domain-mediated MyD88/IL1-RI interaction', 'Product does not compete with ATP.', 'Reversible: no

in vivo

TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)[1].

References

[1] Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6. DOI:10.1073/pnas.0932746100

IL-1R Antagonist Preparation Products And Raw materials

Raw materials

Preparation Products

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IL-1R Antagonist Suppliers

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566914-00-9, IL-1R AntagonistRelated Search:

1-Methylpyrrole N-Methyldiethanolamine

  • IL-1R Antagonist
  • Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-
  • (S)-N-(3-Methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-3-phenylpropanamide
  • Benzenepropanamide, N-[(1S)-2-methyl-1-(pyrrolidinylcarbonyl)propyl]-
  • N-[(2S)-3-Methyl-1-oxo-1-(1-pyrrolidinyl)-2-butanyl]-3-phenylpropanamide
  • IL-1R antagonist(TLR1)
  • TLR1,TLR-1,TLR 1,Inhibitor,MyD88,inhibit
  • I912552 IL-1R Antagonist,98%
  • TLR1, 10 mM in DMSO
  • 566914-00-9