ChemicalBook > CAS DataBase List > 2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)

2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)

Product Name
2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
CAS No.
54198-72-0
Chemical Name
2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
Synonyms
2-Pyrimidinemethanol, 4,6-dimethyl-;(4,6-dimethylpyrimidin-2-yl)methanol;2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
CBNumber
CB11081447
Molecular Formula
C7H10N2O
Formula Weight
138.17
MOL File
54198-72-0.mol
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2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Property

Melting point:
87-88 °C
Boiling point:
235.1±28.0 °C(Predicted)
Density 
1.130±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.75±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D495773
Product name
(4,6-Dimethylpyrimidin-2-yl)methanol
Packaging
500mg
Price
$310
Updated
2021/12/16
AK Scientific
Product number
7790AB
Product name
(4,6-Dimethylpyrimidin-2-yl)methanol
Packaging
1g
Price
$442
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
D15159
Product name
(4,6-Dimethylpyrimidin-2-yl)methanol
Purity
98%
Packaging
1g
Price
$225
Updated
2021/12/16
AK Scientific
Product number
7790AB
Product name
(4,6-Dimethylpyrimidin-2-yl)methanol
Packaging
100mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
7790AB
Product name
(4,6-Dimethylpyrimidin-2-yl)methanol
Packaging
250mg
Price
$184
Updated
2021/12/16
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2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Chemical Properties,Usage,Production

Synthesis

27427-89-0

54198-72-0

General procedure for the synthesis of (4,6-dimethylpyrimidin-2-yl)methanol from methyl 4,6-dimethylpyrimidine-2-carboxylate: 4,6-dimethylpyrimidine-2-carboxylic acid methyl ester (400 mg, 2.40 mmol) was dissolved in ethanol (10 mL) under argon protection and cooled to 0 °C. Sodium borohydride (137 mg, 3.60 mmol) was then added and the reaction was slowly warmed to room temperature and stirred for 2 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with deionized water (15 mL) and extracted with dichloromethane (2 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (4,6-dimethylpyrimidin-2-yl)methanol (285 mg, 86% yield) as a thick slurry. The crude product was used directly in the next reaction without further purification. The product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 6.91 (s, 1H), 4.71 (s, 2H), 2.50 (s, 6H). Liquid chromatography-mass spectrometry (LC-MS) analysis showed a purity of 96.66%, m/z 139.3 (M++1); chromatographic conditions: Eclipse XDB C-18 column (150×4.6 mm, 5 μm), mobile phase 0.05% trifluoroacetic acid/acetonitrile at a flow rate of 1.0 mL/min, and retention time of 4.03 min. TLC unfolding agent was 40% ethyl acetate/hexane (Rf=0.5).

References

[1] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0589; 0590; 0591

2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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54198-72-0, 2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)Related Search:

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  • 2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
  • (4,6-dimethylpyrimidin-2-yl)methanol
  • 2-Pyrimidinemethanol, 4,6-dimethyl-
  • 54198-72-0
  • PYRIMIDINE