agrimol B
- Product Name
- agrimol B
- CAS No.
- 55576-66-4
- Chemical Name
- agrimol B
- Synonyms
- agrimol B;AGRIMOL B(P);(S)-(+)-Agrimol B;Agrimol B (-)-Agrimol B;Agrimol B, 10 mM in DMSO;1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphe;(2S)-1-[3,5-Bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone;1-Butanone,1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-,(2S)-;1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphenyl)-2-methyl-, (S)-;(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)
- CBNumber
- CB11354390
- Molecular Formula
- C37H46O12
- Formula Weight
- 682.75
- MOL File
- 55576-66-4.mol
agrimol B Property
- Boiling point:
- 922.6±65.0 °C(Predicted)
- Density
- 1.292
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 7.09±0.50(Predicted)
- color
- White to yellow
- InChIKey
- BVLHMPZMQVWDGX-INIZCTEOSA-N
- SMILES
- C(C1=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C1O)(=O)[C@@H](C)CC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FA73989
- Product name
- Agrimol B
- Packaging
- 5mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- FA73989
- Product name
- Agrimol B
- Packaging
- 10mg
- Price
- $236.8
- Updated
- 2021/12/16
- Product number
- N2476
- Product name
- AgrimolB
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CS-0009720
- Product name
- AgrimolB
- Purity
- 99.72%
- Packaging
- 5mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- FA73989
- Product name
- Agrimol B
- Packaging
- 25mg
- Price
- $473.5
- Updated
- 2021/12/16
agrimol B Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Agrimony.
Uses
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3].
Biological Activity
Agrimol B, a polyphenol derivative isolated from Agrimony, inhibits adipogenesis, induces the translocation and expression of SIRT1, and reduces the expression of PPARγ.
in vivo
Agrimol B (10 mg/kg, Orally, daily) reduces growth of prostate cancer cell xenograft in mice[2].
| Animal Model: | BALB/c nude mice (6-week-old, male, injected with PC-3 cells in 0.2 mL PBS subcutaneously)[2] |
| Dosage: | 10 mg/kg |
| Administration: | Orally, daily, after 15 days of cancer cell implantation |
| Result: | Inhibited tumor growth in a mouse model of human prostate cancer, reduced the tumor volume at day 31 and day 32. |
target
PPAR | Antifection
IC 50
SIRT1; PPARγ
References
[1] Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. DOI:10.1016/j.bbrc.2016.06.078
[2] Hnit SST, et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. DOI:10.1016/j.biopha.2021.111795
[3] Chun S B, et al. Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB[J]. ?????? ?10? 3?, 2006, 10(3):230-236.
agrimol B Preparation Products And Raw materials
Raw materials
Preparation Products
agrimol B Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from agrimol B manufacturers
- Product
- Agrimol B 55576-66-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-02-26
- Product
- agrimol B 55576-66-4
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24