NSP 805
- Product Name
- NSP 805
- CAS No.
- 125068-54-4
- Chemical Name
- NSP 805
- Synonyms
- NSP 805;NSP-805, 10 mM in DMSO;Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE);5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one;3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-
- CBNumber
- CB11366706
- Molecular Formula
- C17H19N3O2
- Formula Weight
- 297.35
- MOL File
- 125068-54-4.mol
NSP 805 Property
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.84±0.60(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-6788
- Product name
- NSP-805
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-6788
- Product name
- NSP-805
- Purity
- >99.0%
- Packaging
- 10mg
- Price
- $408
- Updated
- 2021/12/16
- Product number
- CS-6788
- Product name
- NSP-805
- Purity
- >99.0%
- Packaging
- 20mg
- Price
- $720
- Updated
- 2021/12/16
NSP 805 Chemical Properties,Usage,Production
Uses
NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.
in vivo
In anesthetized dogs, intravenous (i.v.) injection of NSP-805 produces dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR). The ED50 value for LVdP/dtmax of NSP-805 is 12 μg/kg. When the drugs is administered intraduodenally to anesthetized dogs, the ED50 value for LVdP/dtmax of NSP-805, is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely improves the hemodynamic state of heart failure to normal levels[1]. NSP-805(100 μg/kg) reduces systemic blood pressure significantly, but the increase of chorio-retinal blood flow is less than that at the low dose of NSP-805 (40 μg/kg) in rabbit eyes[2].
References
[1] Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. DOI:10.1097/00005344-199306000-00021
[2] Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20. PMID:12420371
NSP 805 Preparation Products And Raw materials
Raw materials
Preparation Products
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