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NSP 805

Product Name
NSP 805
CAS No.
125068-54-4
Chemical Name
NSP 805
Synonyms
NSP 805;NSP-805, 10 mM in DMSO;Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE);5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one;3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-
CBNumber
CB11366706
Molecular Formula
C17H19N3O2
Formula Weight
297.35
MOL File
125068-54-4.mol
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NSP 805 Property

Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
13.84±0.60(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6788
Product name
NSP-805
Purity
>99.0%
Packaging
5mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-6788
Product name
NSP-805
Purity
>99.0%
Packaging
10mg
Price
$408
Updated
2021/12/16
ChemScene
Product number
CS-6788
Product name
NSP-805
Purity
>99.0%
Packaging
20mg
Price
$720
Updated
2021/12/16
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NSP 805 Chemical Properties,Usage,Production

Uses

NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.

in vivo

In anesthetized dogs, intravenous (i.v.) injection of NSP-805 produces dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR). The ED50 value for LVdP/dtmax of NSP-805 is 12 μg/kg. When the drugs is administered intraduodenally to anesthetized dogs, the ED50 value for LVdP/dtmax of NSP-805, is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely improves the hemodynamic state of heart failure to normal levels[1]. NSP-805(100 μg/kg) reduces systemic blood pressure significantly, but the increase of chorio-retinal blood flow is less than that at the low dose of NSP-805 (40 μg/kg) in rabbit eyes[2].

References

[1] Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. DOI:10.1097/00005344-199306000-00021
[2] Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20. PMID:12420371

NSP 805 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSP 805 Suppliers

China 23 United States 5 Global 28
MedChemexpress LLC
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021-58955995
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609-228-5909
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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Aladdin Scientific
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MedChemExpress
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125068-54-4, NSP 805Related Search:

(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone NSP 805 NSP 804

  • NSP 805
  • 3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-
  • Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE)
  • 5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one
  • NSP-805, 10 mM in DMSO
  • 125068-54-4