5-Bromo-1,3-dichloro-2-fluorobenzene
Uses- Product Name
- 5-Bromo-1,3-dichloro-2-fluorobenzene
- CAS No.
- 17318-08-0
- Chemical Name
- 5-Bromo-1,3-dichloro-2-fluorobenzene
- Synonyms
- 3-dichloro-2-fluorobenzene;3,5-Dichloro-4-fluorobromobenzene;3,5-dichloro-4-fluoro-1-bromobenzene;3,5-dichloro-4-fluorobroMobezene;3,5-dichloro-4-bromofluorobenzene;2,6-dichloro-4-bromofluorobenzene;5-Bromo-1,3-chloro-2-fluorobenzene;5-BROMO-1,3-DICHLORO-2-FLUOROBENZEN;1-BroMo-3,5-dichloro-4-fluorobenzene;3,5-dichllor-4-fluoro-1-bromobenzene
- CBNumber
- CB11462691
- Molecular Formula
- C6H2BrCl2F
- Formula Weight
- 243.89
- MOL File
- 17318-08-0.mol
5-Bromo-1,3-dichloro-2-fluorobenzene Property
- Boiling point:
- 234℃
- Density
- 1.823
- vapor pressure
- 23.8-112Pa at 30-50℃
- refractive index
- 1.567
- Flash point:
- 96℃
- storage temp.
- Sealed in dry,2-8°C
- form
- Liquid
- Appearance
- Colorless to off-white <23°C Solid,>29°C Liquid
- InChI
- InChI=1S/C6H2BrCl2F/c7-3-1-4(8)6(10)5(9)2-3/h1-2H
- InChIKey
- MMJSIYGLDQNUTH-UHFFFAOYSA-N
- SMILES
- C1(Cl)=CC(Br)=CC(Cl)=C1F
- LogP
- 4.4 at 20℃ and pH7
- CAS DataBase Reference
- 17318-08-0
Safety
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B691093
- Product name
- 5-Bromo-1,3-dichloro-2-fluorobenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB37176
- Product name
- 5-Bromo-1,3-dichloro-2-fluorobenzene
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC8928
- Product name
- 3,5-Dichloro-4-fluorobromobenzene
- Packaging
- 100g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 1600-F-X5
- Product name
- 3,5-Dichloro-4-fluorobromobenzene
- Packaging
- 25g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 074078
- Product name
- 5-Bromo-1,3-dichloro-2-fluorobenzene
- Purity
- 95+%
- Packaging
- 25g
- Price
- $69
- Updated
- 2021/12/16
5-Bromo-1,3-dichloro-2-fluorobenzene Chemical Properties,Usage,Production
Uses
3,5-Dichloro-4-fluorobromobenzene is an organic synthesis intermediate that can be used in laboratory organic synthesis and pharmaceutical research and development.
Chemical Properties
light yellow liquid
Synthesis
60811-21-4
17318-08-0
The general procedure for the synthesis of 3,5-dichloro-4-fluorobromobenzene from 3-chloro-4-fluorobromobenzene was as follows: to a dry Schlenk flask equipped with a magnetic stirrer and septum under argon protection was added 20 mL of freshly titrated iPrMgCl-LiCl (1.24 M, THF solution, 1.0 equiv.), followed by a slow dropwise addition of 3.8 mL of diisopropylamine (1.1 equiv.) ). The reaction mixture was stirred at room temperature until complete gas release (~48 hours). The precipitate formed was dissolved with additional dry THF. A fresh solution of iPr2NMgCl-LiCl in THF was titrated at 25 °C using benzoic acid and 4-(phenylazo)diphenylamine as indicators, and the concentration was measured to be 0.59 M. 4-Bromo-2-chloro-1-fluorobenzene (0.209 g, 1.00 mmol) was dissolved in THF (1 mL) and iPr2NMgCl-LiCl (0.59 M , 3.39 mL, 2.00 mmol) solution was added and stirred at 25 °C for 15 min. Subsequently, hexachloro-2-acetone (0.397 g, 1.50 mmol) was added at 0 °C and stirring was continued for 15 min. The reaction mixture was quenched with saturated aqueous NaHCO3 solution, extracted with ethyl acetate and the organic phase was dried over anhydrous Na2SO4. After filtration, the solvent was concentrated under reduced pressure. Quantitative GC analysis showed the ratio of 5-bromo-1,3-dichloro-2-fluorobenzene to the regional isomers to be about 12:1. Purification by fast column chromatography (silica gel, n-hexane) afforded 5-bromo-1,3-dichloro-2-fluorobenzene (0.190 g) as a colorless oil.
References
[1] Patent: WO2016/58895, 2016, A1. Location in patent: Page/Page column 7; 8
5-Bromo-1,3-dichloro-2-fluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-1,3-dichloro-2-fluorobenzene Suppliers
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- sales@carbosynth.com
- Country
- United Kingdom
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View Lastest Price from 5-Bromo-1,3-dichloro-2-fluorobenzene manufacturers
- Product
- 5-Bromo-1,3-dichloro-2-fluorobenzene 17318-08-0
- Price
- US $1.00/g
- Min. Order
- 300g
- Purity
- 99.8%
- Supply Ability
- 20 TONS
- Release date
- 2025-11-04
- Product
- 3,5-Dichloro-4-fluorobromobenzene 17318-08-0
- Price
- US $168.00/KG
- Min. Order
- 1KG
- Purity
- 98%+
- Supply Ability
- 300MT/year
- Release date
- 2019-12-24
- Product
- 5-Bromo-1,3-dichloro-2-fluorobenzene 17318-08-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-12-25