ChemicalBook > CAS DataBase List > 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

Product Name
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
CAS No.
179688-53-0
Chemical Name
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
Synonyms
7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate;4-hydroxy-7-methoxyquinazolin-6-yl acetate;Gefitinib IMpurity VII;Gefitinib interMidiate IV;Gefitinib Intermediate IV;6-Acetoxy-7-methoxy-4-quinazolinol;6-Acetoxy-7-methoxy-4-quinazolinone;6-Acetoxy-7-methoxy-3H-quinazolin-4-one;6-ACETOXY-7-METHPXY-4-(3H)QUINAZOLINONE;6-Acetoxy-7-Methoxy-4(3H)-quinazolinone
CBNumber
CB11503967
Molecular Formula
C11H10N2O4
Formula Weight
234.21
MOL File
179688-53-0.mol
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3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Property

Melting point:
293 °C
Boiling point:
390.5±52.0 °C(Predicted)
Density 
1.39
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
powder to crystal
pka
0.67±0.20(Predicted)
color 
White to Yellow
InChI
InChI=1S/C11H10N2O4/c1-6(14)17-10-3-7-8(4-9(10)16-2)12-5-13-11(7)15/h3-5H,1-2H3,(H,12,13,15)
InChIKey
SOLQIFINSOHAQD-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(OC(C)=O)C(OC)=C2)C(=O)NC=1
CAS DataBase Reference
179688-53-0
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Safety

HS Code 
2933.79.1500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2717
Product name
6-Acetoxy-7-methoxy-3H-quinazolin-4-one
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
A2717
Product name
6-Acetoxy-7-methoxy-3H-quinazolin-4-one
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$94
Updated
2025/07/31
TRC
Product number
H825780
Product name
4-Hydroxy-7-methoxyquinazolin-6-ylEsterAceticAcid
Packaging
5g
Price
$150
Updated
2021/12/16
TRC
Product number
H825780
Product name
4-Hydroxy-7-methoxyquinazolin-6-ylEsterAceticAcid
Packaging
10g
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD76469
Product name
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
Packaging
10g
Price
$160
Updated
2021/12/16
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3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Chemical Properties,Usage,Production

Chemical Properties

Brown solid powder

Uses

4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid exhibit potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7.

Synthesis

108-24-7

179688-52-9

179688-53-0

6-Hydroxy-7-methoxyquinazolin-4-one (1.92 g, 10 mmol) was placed in acetic anhydride (20 mL) and pyridine (4 mL) was added slowly with stirring. The reaction mixture was heated to 100 °C and kept for 4 hours. After the reaction was completed, it was cooled to room temperature and ice water was added to quench the reaction. The white solid that precipitated was the intermediate 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-ol acetate (M-1, 2.32 g, 99% yield).

References

[1] Patent: CN106632089, 2017, A. Location in patent: Paragraph 0077; 0078; 0079
[2] Patent: CN106045980, 2016, A. Location in patent: Paragraph 0018; 0019; 0020
[3] Patent: EP1785420, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US2007/149523, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2005/97134, 2005, A2. Location in patent: Page/Page column 13; figure 1

3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Suppliers

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View Lastest Price from 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kg
Release date
2021-10-22
Nanjing Fred Technology Co., Ltd
Product
3,4-dihydro-7-methoxy-4-oxo-quinazolin-6-yl acetate 179688-53-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%(HPLC)
Supply Ability
2tons
Release date
2023-12-13
henan kanbei chemical co.,ltd
Product
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2022-09-26

179688-53-0, 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetateRelated Search:

Benzaldehyde, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- 3-(3-morpholinylpropoxy)-4-methoxybenzonitrile 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 4-(3-Chloropropyl)morpholine Cefazolin Cefazolin sodium salt Glatiramer acetate Potassium Acetate Vinyl acetate Butyl acetate Methyl acetate Ethyl acetate Sodium acetate Tocopheryl acetate O-Desmethyl Gefitinib 4-Defluoro-4-hydroxy Gefitinib Gefitinib Impurity 14 N-(3-chloro-4-fluorophenyl)-6 ,7-dimethoxyquinazolin-4-amine

  • 7-Methoxy-4-oxo-1,4-dihydroquinazolin-6-yl acetate
  • 6-Acetoxy-7-methoxy-3H-quinazolin-4-one
  • 4-hydroxy-7-methoxyquinazolin-6-yl acetate
  • 6-methoxy-4-oxo-3,4-dihydroquinazolin-7-yl acetate
  • (7-methoxy-4-oxo-1H-quinazolin-6-yl) acetate
  • 6-Acetoxy-7-methoxy-3<i>H</i>-quinazolin-4-one
  • 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4(3H)-one
  • 4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
  • 6-ACETOXY-7-METHPXY-4-(3H)QUINAZOLINONE
  • 3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline
  • 6-(Acetyloxy)-7-methoxy-4(3H)-quinazolinone
  • 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
  • Gefitinib interMidiate IV
  • 7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate
  • 6-Acetoxy-7-Methoxy-4(3H)-quinazolinone
  • (4(3H)-Quinazolinone,6-(acetyloxy)-7-Methoxy- )
  • Gefitinib IMpurity VII
  • 6-acetoxy-7-Methoxy-3,4-dihydroquizolin-4-one
  • 6-Acetoxy-7-methoxyquinazolin-4(3H)-one
  • acetic acid (7-methoxy-4-oxo-1H-quinazolin-6-yl) ester
  • 6-Acetoxy-7-methoxy-3H-quinazolin-4-one &gt
  • Acetic acid 7-methoxy-4-oxo-1,4-dihydro-quinazolin-6-yl ester
  • 6-O-Acetyl-4-hydroxy-7-methoxy quinazoline
  • 6-Acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
  • 6-Acetoxy-7-methoxy-4-hydroxyquinazoline
  • 6-Acetoxy-7-methoxy-4-quinazolinol
  • 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0
  • 6-(Acetyloxy)-7-methoxyquinazolin-4(3H)-one
  • Gefitinib Intermediate IV
  • 6-Acetoxy-7-methoxy-4-quinazolinone
  • 3,4-Dihydro-7-methoxy-4-oxoquinoline-6-acetate
  • 179688-53-0