ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE
- Product Name
- ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE
- CAS No.
- 13616-37-0
- Chemical Name
- ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE
- Synonyms
- AKOS BBS-00005306;TIMTEC-BB SBB001698;Cefazolin Impurity 39;5- Ethyl acetate tetrazol;ETHYL(TETRAZOL-5-YL)ACETATE;Ethyl 2H-tetrazole-5-acetate;ETHYL 2H-TETRAZOL-5-YLACETATE;ETHYL 1 H-TETRAZOLE-5-ACETATE;Ethyl1H-Tetrazole-5-acetate>Ethyl 1H-tetrazole-5-acetate 97%
- CBNumber
- CB1153451
- Molecular Formula
- C5H8N4O2
- Formula Weight
- 156.14
- MOL File
- 13616-37-0.mol
ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE Property
- Melting point:
- 123-127 °C (lit.)
- Boiling point:
- 312.3±44.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.31±0.10(Predicted)
- color
- White to Almost white
- InChIKey
- NAOHMNNTUFFTBF-UHFFFAOYSA-N
- CAS DataBase Reference
- 13616-37-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 436917
- Product name
- Ethyl 1H-tetrazole-5-acetate
- Purity
- 97%
- Packaging
- 10g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- E0859
- Product name
- Ethyl 1H-Tetrazole-5-acetate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- E0859
- Product name
- Ethyl 1H-Tetrazole-5-acetate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $264
- Updated
- 2025/07/31
- Product number
- E926840
- Product name
- Ethyl2-(2H-Tetrazol-5-yl)acetate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000073566
- Product name
- Ethyl 2-(2H-tetrazol-5-yl)acetate
- Purity
- 97%
- Packaging
- 5g
- Price
- $59
- Updated
- 2021/12/16
ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE Chemical Properties,Usage,Production
Uses
Ethyl 1H-tetrazole-5-acetate (Ethyl 1H-tetrazole-5-yl acetate, Hetza) may be employed as starting reagent for the synthesis of ethyl aryloxadiazolylacetates. It may be used for the preparation of homochiral 3D diamondoid metal-organic framework [Zn2(etza)4].
General Description
Ethyl 1H-tetrazole-5-acetate is a tetrazole derivative. Its effect on glutaminyl cyclase activity of the recombinant human glutaminyl cyclase (QC) has been reported.
Synthesis
105-56-6
13616-37-0
General procedure for the synthesis of ethyl 1H-tetrazole-5-acetate from ethyl cyanoacetate: general method: a mixture of ethyl cyanoacetate (1 mmol), sodium azide (1.25 mmol) and L-proline (30 mol%) in N,N-dimethylformamide (DMF, 5 mL) was stirred and reacted for 1-2 hours at 110°C. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature. The cooled reaction mixture was slowly poured into ice water (15 mL) under stirring. Subsequently, the resulting mixture was acidified with dilute hydrochloric acid under vigorous stirring to pH < 3. If a solid product precipitated after acidification, the solid was collected by filtration and washed with plenty of cold water until the washings were neutral. The resulting solid product was air dried at room temperature to give pure ethyl 1H-tetrazole-5-acetate. If no solid product precipitated after acidification (e.g., when benzyl cyanide or aliphatic nitrile was used as the raw material), the aqueous phase of acidification was extracted with ethyl acetate (2 x 20 mL), and the organic phases were combined and washed with deionized water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the corresponding pure ethyl 1H-tetrazole-5-acetate.
References
[1] New Journal of Chemistry, 2013, vol. 37, # 10, p. 3261 - 3266
[2] Monatshefte fur Chemie, 2013, vol. 144, # 9, p. 1407 - 1410
[3] Synthetic Communications, 2010, vol. 40, # 17, p. 2624 - 2632
[4] Heterocycles, 2014, vol. 89, # 9, p. 2137 - 2150
[5] Synlett, 2018, vol. 29, # 7, p. 874 - 879
ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE Preparation Products And Raw materials
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View Lastest Price from ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE manufacturers
- Product
- ETHYL 2-(2H-1,2,3,4-TETRAAZOL-5-YL)ACETATE 13616-37-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-01