2-chloro-N-(2,2,2-trifluoroethyl)acetamide
- Product Name
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
- CAS No.
- 170655-44-4
- Chemical Name
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
- Synonyms
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide;2-CgHLORO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE;AcetaMide, 2-chloro-N-(2,2,2-trifluoroethyl)-
- CBNumber
- CB11690689
- Molecular Formula
- C4H5ClF3NO
- Formula Weight
- 175.54
- MOL File
- 170655-44-4.mol
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Property
- Boiling point:
- 218 ºC
- Density
- 1.368
- Flash point:
- 86 ºC
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.89±0.46(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H5ClF3NO/c5-1-3(10)9-2-4(6,7)8/h1-2H2,(H,9,10)
- InChIKey
- IRIXZMVHMMALGW-UHFFFAOYSA-N
- SMILES
- C(NCC(F)(F)F)(=O)CCl
Safety
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C422155
- Product name
- 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- HCH0321676
- Product name
- 2-CHLORO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.72
- Updated
- 2021/12/16
- Product number
- 097141
- Product name
- 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $645
- Updated
- 2021/12/16
- Product number
- CS-W021673
- Product name
- 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
- Purity
- >98.0%
- Packaging
- 10g
- Price
- $528
- Updated
- 2021/12/16
- Product number
- CS-W021673
- Product name
- 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Chemical Properties,Usage,Production
Synthesis
373-88-6
79-04-9
170655-44-4
GENERAL STEPS: 30.4 g (759.3 mmol) of sodium hydroxide and 50 mL of water were added to a 500 mL four-necked flask and stirred at room temperature until completely dissolved, then cooled to 5 °C. A solution was prepared by dissolving 50 g (370.4 mmol) of 2,2,2-trifluoroethylamine hydrochloride in 60 mL of water and added slowly and dropwise to the above sodium hydroxide solution at 5 °C. 85 mL of tert-butyl methyl ether was added and stirred continuously for 30 minutes. Subsequently, a solution of 43.9 g (388.9 mmol) of chloroacetyl chloride dissolved in 15 mL of tert-butyl methyl ether was added slowly dropwise while maintaining 5°C. The reaction mixture was heated to 10 °C and stirring was continued for 1 hour. After confirming complete consumption of 2,2,2-trifluoroethylamine by gas chromatography, the reaction mixture was warmed up to room temperature and partitioned. The aqueous layer was extracted with 100 mL of tert-butyl methyl ether, all organic layers were combined, and the solvent was concentrated by distillation under reduced pressure to give a tert-butyl methyl ether solution of 2-chloro-N-(2,2,2-trifluoroethyl)acetamide. The product was analyzed by high performance liquid chromatography with internal standard method to give 65 g of product in 100% yield and a solution concentration of 25.1% by weight. The solution was added dropwise to heptane to induce crystallization, and the melting point of the resulting 2-chloro-N-(2,2,2-trifluoroethyl)acetamide was 53.8 °C (as determined by DSC).
References
[1] Patent: JP5652628, 2015, B2. Location in patent: Paragraph 0057
[2] Inorganic Chemistry, 2018, vol. 57, # 17, p. 11252 - 11263
[3] Chemical Communications, 2016, vol. 52, # 96, p. 13885 - 13888
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-chloro-N-(2,2,2-trifluoroethyl)acetamide manufacturers
- Product
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide 170655-44-4
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09
- Product
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide 170655-44-4
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09