Guanidine carbonate Property

Melting point:

>300 °C(lit.)

Density 

1.25

vapor pressure 

0Pa at 25℃

storage temp. 

Store below +30°C.

solubility 

450g/l

form 

Crystalline Powder

pka

12.5[at 20 ℃]

color 

White to almost white

PH

11.7 (110g/l, H2O, 20℃)

Water Solubility 

450 g/L (20 ºC)

BRN 

3628359

InChIKey

KMSRVXJGTIRNNK-UHFFFAOYSA-N

LogP

-1.63 at 20℃

CAS DataBase Reference

593-85-1(CAS DataBase Reference)

NIST Chemistry Reference

Guanidine carbonate(593-85-1)

EPA Substance Registry System

Guanidine carbonate (2:1) (593-85-1)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-36-22

WGK Germany 

3

RTECS 

FG1750000

Autoignition Temperature

530 °C

TSCA 

Yes

HS Code 

29252000

Toxicity

LD50 orally in Rabbit: 1045 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

Guanidine carbonate Chemical Properties,Usage,Production

High purity Guanidine carbonate synthesis method

Guanidine carbonate is an extremely versatile organic chemical products, it is mainly used in flame retardants, flocculants, foaming agents, synthetic sulfa drugs, etc. Guanidine carbonate is also used as synthetic detergent builders, high-quality cosmetics raw materials.Synthesis of guanidine carbonate is reported by many literatures [1-3] .The main domestic guanidine carbonate production is that molt dicyandiamide and ammonium chloride to generate guanidine hydrochloride, generate free guanidine under the action of the alkali, and then by the reaction of free guanidine and carbon dioxide to produce guanidine carbonate. this route is easy to generate melamine and its dimers, trimers and other impurities because of the high-temperature melting , and the presence of Cl-, Na + in the system is difficult to completely removed , even if the purity is> 99% of guanidine carbonate, its ash content is still up 0.2%, it is difficult to obtain high purity guanidine carbonate. in this paper, cyanamide as raw materials, reacts with carbon dioxide and ammonia in one step synthesis of guanidine carbonate, also known as ash-free guanidine carbonate, and then purify , to obtain a high purity guanidine carbonate, the reaction equation is as follows: 2NH2CN + CO2 + 2NH3 + H20 → [NH2C (: NH) NH2] 2H2CO3
Author: Zhouzhao Liang Xie Jianwei Zhou Xiaohong Jiang Yongqing
Author: Zhouzhao Liang, Xie Jianwei (Research Institute of Zhejiang University of West Branch Quzhou 324006)
Zhou Xiaohong, Jiang Yongqing (Institute of Fine Chemicals Group Technology Center Juhua Quzhou 324004)

Reference quality standards

[Industry Grade ] Name of Item Technical index
Premium grade B product
Appearance white crystalline white powder
Content of ≥ 99% 98%
Ammonium ≤ 0.45% 1.0%
Water insoluble matter ≤ 0.2% 0.2%
Moisture ≤ 0.2% 0.2%
Ash ≤ 0.15% 0.2%
Water-soluble test Qualified Qualified
PH value (4% 25 ℃) 11.4 11.4
[Pharmaceutical Grade ]
Name of Item Technical index
Premium grade
Appearance white crystals
Content ≥ 99%
Ammonium salt (with NH4Cl meter) ≤ 0.45%
Water insoluble matter ≤ 0.2%
Moisture ≤ 0.2%
Ash ≤ 0.1%
Water-soluble test Qualified
PH value (4% 25 ℃) 11.4
Heavy Metal ppm ≤10
Arsenic ppm ≤3
The above information is edited by the Chemicalbook of Tian Ye.

Chemical Properties

white to almost white crystalline powder. Soluble in water, slightly soluble in methanol, almost insoluble in acetone, benzene and ether.

Uses

Guanidine Carbonate is a strong organic alkali. It is used to adjust the pH of a formulation, organic intermediate, soap and cosmetic products.

Uses

Guanidine Carbonate is used in the cytidine triphosphate injection stabilization. It also acts as a powerful and versatile protein denaturants.
As a strong chemical base, guanidine carbonate is used as an intermediary in a variety of applications:
Organic synthesis materials and analytical reagents.
pH adjusting agents for amino resins, antioxidants, resin stabilizer and guanidine soap, also a grout agent, cement additives, surfactants.
In terms of synthetic detergent,it is used as a moisture agent and a synergist.
For Zinc, cadmium, manganese weight measurement, it is used as a precipitating agent, it is also used in the separation of alkali metal magnesium.

Application

Guanidine carbonate salt can be used as a reactant for the synthesis of:
An oxidizer, guanidinium dinitramide (GDN), by reacting with ammonium dinitramide.
Guanidinium cyclopropanecarboxylate by reacting with cyclopropanecarboxylic acid.

Preparation

Synthesis of guanidine carbonate: Melt double cyanide salts and ammonia to generate guanidine salts (guanidine hydrochloride, guanidine nitrate) at 170-230 ℃ . Then make guanidine salt into an alcohol solution, add soda to free guanidine, absorb carbon dioxide to obtain guanidine carbonate.

Hazard

Toxic by ingestion.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from MeOH. [Beilstein 3 H 86, 3 I 41, 3 II 72, 3 III 161, 3 IV 152.]