ChemicalBook > CAS DataBase List > EO 1428
EO 1428
- Product Name
- EO 1428
- CAS No.
- 321351-00-2
- Chemical Name
- EO 1428
- Synonyms
- EO 1428;p38 MAPK Inhibitor VIII;p38 MAP Kinase Inhibitor VIII;(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone;Methanone, [4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)-
- CBNumber
- CB12455755
- Molecular Formula
- C20H16BrClN2O
- Formula Weight
- 415.71
- MOL File
- 321351-00-2.mol
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EO 1428 Property
- storage temp.
- Store at +4°C
- solubility
- Soluble to 100 mM in DMSO and to 50 mM in ethanol
- form
- Powder
- color
- yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 506163
- Product name
- p38 MAP Kinase Inhibitor VIII
- Purity
- The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &
- Packaging
- 5 mg
- Price
- $266
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 21229
- Product name
- p38 MAPK Inhibitor VIII
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21229
- Product name
- p38 MAPK Inhibitor VIII
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21229
- Product name
- p38 MAPK Inhibitor VIII
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
Tocris
- Product number
- 2908
- Product name
- EO1428
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $225
- Updated
- 2021/12/16
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EO 1428 Chemical Properties,Usage,Production
Uses
EO 1428 is a p38 MAP kinase inhibitor with high antiinflammatory activity.
Definition
ChEBI: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone is a member of benzophenones.
Biological Activity
Selective inhibitor of p38 α and p38 β 2 that displays no activity at p38 γ , p38 δ , ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF- α , IL-6, IL-1 β and IL-10 (IC 50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.
storage
Store at +4°C
EO 1428 Preparation Products And Raw materials
Raw materials
Preparation Products
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EO 1428 Suppliers
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