ChemicalBook > CAS DataBase List > N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
- Product Name
- N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
- CAS No.
- 527680-56-4
- Chemical Name
- N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
- Synonyms
- PH-568487;PHA 568487;PHA 568487 free base;(R)-N-(Quinuclidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide;1,4-Benzodioxin-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE;macrophage,fracture,acetylcholine,Inhibitor,ischemic,bone,receptor,PHA 568487 free base,cerebral,middle,Post-stroke,stroke,inhibit,PHA568487,memory,oxidative,polarization,dysfunction,Nicotinic acetylcholine receptors,occlusion,PHA-568487,neuroinflammation,nicotinic,artery,stress,nAChR
- CBNumber
- CB12456358
- Molecular Formula
- C16H20N2O3
- Formula Weight
- 288.34
- MOL File
- 527680-56-4.mol
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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Property
- storage temp.
- Desiccate at RT
- solubility
- <40.44mg/ml in Water; <40.44mg/ml in DMSO
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Tocris
- Product number
- 3134
- Product name
- PHA568487
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
Tocris
- Product number
- 3134
- Product name
- PHA568487
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $742
- Updated
- 2021/12/16
TRC
- Product number
- P294493
- Product name
- PHA568487
- Packaging
- 25mg
- Price
- $230
- Updated
- 2021/12/16
Usbiological
- Product number
- 462342
- Product name
- PHA 568487
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
Usbiological
- Product number
- 256227
- Product name
- PHA 568487
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Chemical Properties,Usage,Production
Uses
PHA 568487 is an agonist of AChR α7.
in vivo
PHA 568487 treatment reduces mouse cognitive decline caused by aseptic bone fracture by promoting inflammation resolution. PHA 568487 (PHA; 0.8 mg/kg; injected intraperitoneally) reduces infarct volume and TUNEL positive neurons in the peri-infarct regions of permanent middle cerebral artery occlusion (pMCAO) and pMCAO+tibia fracture mice[2].
The role played by a7 receptors on neuroinflammation is supported by the decrease of [18F]DPA-714 binding in ischemic rats treated with the a7 agonist PHA 568487 at day 7 after MCAO[3].
PHA 568487-treated ischemic rats show a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome compared with non-treated MCAO rats[3].
| Animal Model: | C57BL/6J male mice (10-12 weeks old) with pMCAO[2] |
| Dosage: | 0.4 and 0.8 mg/kg |
| Administration: | Injected intraperitoneally once on day 1, or twice on days 1 and 2, after pMCAO |
| Result: | 0.8 mg/kg on days 1 and 2 after pMCAO yielded the best effect on infarct volume and behavior tests. |
| Animal Model: | Adult male Sprague-Dawley rats[3] |
| Dosage: | 1.25 mg/kg |
| Administration: | Treated i.p. daily with 0.1 mL |
| Result: | Showed a significant decrease of [18F]DPA-714 binding in the ischemic cerebral hemisphere in comparison to non-treated ischemic rats. |
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Suppliers
- Tel
- --
- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77