17(S)-HpDoHE

Product Name: 17(S)-HpDoHE
CAS No.: 123673-33-6
Chemical Name: 17(S)-HpDoHE
Synonyms: 17(S)-HpDHA;17(S)-HpDoHE;BNHQALRBDJVUQB-YTQNUIGOSA-N;17(S)-HpDHA(solution in ethanol);17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-DHA;17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-Docosahexaenoic acid;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroperoxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-
CBNumber: CB12589933
Molecular Formula: C22H32O4
Formula Weight: 360.49
MOL File: 123673-33-6.mol

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17(S)-HpDoHE Property

storage temp.: Store at -20°C
solubility: DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13185
Product name: 17(S)-HpDHA
Purity: ≥98%
Packaging: 25μg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 13185
Product name: 17(S)-HpDHA
Purity: ≥98%
Packaging: 50μg
Price: $241
Updated: 2024/03/01

Cayman Chemical

Product number: 13185
Product name: 17(S)-HpDHA
Purity: ≥98%
Packaging: 100μg
Price: $455
Updated: 2024/03/01

Cayman Chemical

Product number: 13185
Product name: 17(S)-HpDHA
Purity: ≥98%
Packaging: 250μg
Price: $947
Updated: 2024/03/01

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17(S)-HpDoHE Chemical Properties,Usage,Production

Description

17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-HpDHA is generally reduced to 17(S)-HDHA , a compound that serves as a precursor to 17(S)-resolvins. 17(S)-HDHA has been shown to inhibit TNF-α-induced interleukin-1β expression in human glioma cells and inhibit TNF-α-induced leukocyte trafficking to the murine air pouch.

Uses

17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM[1].

Definition

ChEBI: (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid is a docosanoid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying a hydroperoxy substituent at position 17S. It has a role as a mouse metabolite. It is a docosanoid, a long-chain fatty acid and a hydroperoxy polyunsaturated fatty acid. It is functionally related to an all-cis-docosa-4,7,10,13,16,19-hexaenoic acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate.

References

[1] Tsai WC, et al. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 Jun 8;60(22):1741-1754. DOI:10.1021/acs.biochem.0c00931

17(S)-HpDoHE Preparation Products And Raw materials

Raw materials

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17(S)-HpDoHE Suppliers

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123673-33-6, 17(S)-HpDoHERelated Search:

17(S)-HpDoHE

17(S)-HpDHA

BNHQALRBDJVUQB-YTQNUIGOSA-N

4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroperoxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-

17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-Docosahexaenoic acid

17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-DHA

17(S)-HpDHA(solution in ethanol)

123673-33-6