CAY10614

Product Name: CAY10614
CAS No.: 1202208-36-3
Chemical Name: CAY10614
Synonyms: CAY10614;CAY10614 Exclusive;cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide;N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
CBNumber: CB12590443
Molecular Formula: C42H78INO2
Formula Weight: 756
MOL File: 1202208-36-3.mol

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CAY10614 Property

storage temp.: Store at -20°C
solubility: DMF: 0.15 mg/ml; DMSO: 0.14 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13615
Product name: CAY10614
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 13615
Product name: CAY10614
Purity: ≥98%
Packaging: 5mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 13615
Product name: CAY10614
Purity: ≥98%
Packaging: 10mg
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 13615
Product name: CAY10614
Purity: ≥98%
Packaging: 25mg
Price: $914
Updated: 2024/03/01

AK Scientific

Product number: 1922AH
Product name: N-Cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium,iodide
Packaging: 1mg
Price: $158
Updated: 2021/12/16

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CAY10614 Chemical Properties,Usage,Production

Description

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC₅₀ value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.¹ It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.¹

Uses

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model[1][2].

in vivo

CAY10614 (compound 7) (10 mg/kg; i.p. 30 min before the LPS) significantly improves survival of mice given intraperitoneal LPS (20 mg/kg)^[1].

Animal Model:	C57BL/6J male mice (9 weeks) were i.p. injected with 20 mg/kg LPS^[1]
Dosage:	10 mg/kg
Administration:	I.p. 30 min before the LPS
Result:	Increased the survival rate of mice from 0% to 67%.

IC 50

TLR4: 1.675 μM (IC₅₀, in HEK293 cells)

References

1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization J. Med. Chem. 52(4),1209-1213(2009).

CAY10614 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10614 Suppliers

China 24 United States 4 Global 28

BOC Sciences

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Shanghai Xingui Biotechnology Co., Ltd.

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BOC Sciences

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Beijing Solarbio Science & Tecnology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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TargetMol Chemicals Inc.

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RD International Technology Co., Limited

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Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
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1202208-36-3, CAY10614Related Search:

CAY10614

N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide

CAY10614 Exclusive

cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide

1202208-36-3