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CAY10614

Product Name
CAY10614
CAS No.
1202208-36-3
Chemical Name
CAY10614
Synonyms
CAY10614;CAY10614 Exclusive;cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide;N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
CBNumber
CB12590443
Molecular Formula
C42H78INO2
Formula Weight
756
MOL File
1202208-36-3.mol
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CAY10614 Property

storage temp. 
Store at -20°C
solubility 
DMF: 0.15 mg/ml; DMSO: 0.14 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13615
Product name
CAY10614
Purity
≥98%
Packaging
1mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
13615
Product name
CAY10614
Purity
≥98%
Packaging
5mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
13615
Product name
CAY10614
Purity
≥98%
Packaging
10mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
13615
Product name
CAY10614
Purity
≥98%
Packaging
25mg
Price
$914
Updated
2024/03/01
AK Scientific
Product number
1922AH
Product name
N-Cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium,iodide
Packaging
1mg
Price
$158
Updated
2021/12/16
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CAY10614 Chemical Properties,Usage,Production

Description

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.1 It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.1

Uses

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model[1][2].

in vivo

CAY10614 (compound 7) (10 mg/kg; i.p. 30 min before the LPS) significantly improves survival of mice given intraperitoneal LPS (20 mg/kg)[1].

Animal Model:C57BL/6J male mice (9 weeks) were i.p. injected with 20 mg/kg LPS[1]
Dosage:10 mg/kg
Administration:I.p. 30 min before the LPS
Result:Increased the survival rate of mice from 0% to 67%.

IC 50

TLR4: 1.675 μM (IC50, in HEK293 cells)

References

1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization J. Med. Chem. 52(4),1209-1213(2009).

CAY10614 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10614 Suppliers

China 24 United States 4 Global 28
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1202208-36-3, CAY10614Related Search:


  • CAY10614
  • N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide
  • CAY10614 Exclusive
  • cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide
  • 1202208-36-3