5-Chloro-3-nitropyridine-2-carboxaldehyde

Product Name: 5-Chloro-3-nitropyridine-2-carboxaldehyde
CAS No.: 1086838-13-2
Chemical Name: 5-Chloro-3-nitropyridine-2-carboxaldehyde
Synonyms: 5-Chloro-3-nitropicolinaldehyde;5-chloro-3-nitropyridine-2-carbaldehyde;5-Chloro-3-nitropyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde, 5-chloro-3-nitro-
CBNumber: CB12629929
Molecular Formula: C6H3ClN2O3
Formula Weight: 186.55
MOL File: 1086838-13-2.mol

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5-Chloro-3-nitropyridine-2-carboxaldehyde Property

Boiling point:: 289.2±40.0 °C(Predicted)
Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.49±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 2311DW
Product name: 5-Chloro-3-nitropicolinaldehyde
Packaging: 10g
Price: $2665
Updated: 2021/12/16

Ambeed

Product number: A154570
Product name: 5-Chloro-3-nitropicolinaldehyde
Purity: 95+%
Packaging: 50mg
Price: $107
Updated: 2021/12/16

Ambeed

Product number: A154570
Product name: 5-Chloro-3-nitropicolinaldehyde
Purity: 95+%
Packaging: 100mg
Price: $178
Updated: 2021/12/16

Ambeed

Product number: A154570
Product name: 5-Chloro-3-nitropicolinaldehyde
Purity: 95+%
Packaging: 250mg
Price: $257
Updated: 2021/12/16

Ambeed

Product number: A154570
Product name: 5-Chloro-3-nitropicolinaldehyde
Purity: 95+%
Packaging: 1g
Price: $418
Updated: 2021/12/16

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5-Chloro-3-nitropyridine-2-carboxaldehyde Chemical Properties,Usage,Production

Synthesis

1086838-15-4

1086838-13-2

The general procedure for the synthesis of 5-chloro-3-nitropyridine-2-carbaldehyde from the compound (CAS:1086838-15-4) is as follows: first, 2-amino-3-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropanenitrile (39 mg) was prepared in quantitative amounts according to a method similar to that described in the preceding. Referring to the operation of Example 1 part b, but using 1-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)propan-2-one (32 mg) as a starting material. 1-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)propan-2-one was prepared similarly as described in Example 105. Next, the method of Example 136 parts a to d was followed, but using 5-chloro-3-nitropyridine-2-carboxaldehyde (1.2 g) and decaborane from part a to prepare [2-(tert-butyldimethylsilyloxy)propyl]-(5-chloro-3-nitropyridin-2-yl)methanamine (0.4 g in 17% yield). 5-chloro-3-nitropyridine-2-carboxaldehyde was prepared similarly to that described in Example 136 parts a to c, with the difference that one starts with 2-amino-5-chloro-3-nitropyridine in part a or uses commercially available 2-bromo-5-chloro-3-nitropyridine as a starting material for part b. The method of preparing 5-chloro-3-nitropyridine-2-carbaldehyde is similar to that described in Example 136 parts a to c. Additionally, the ozonolysis step of part c can be replaced by oxidative cracking using a 4% aqueous osmium tetroxide solution (2 mL) and sodium periodate (1.2 g) in a mixture of THF and water (10:1, 20 mL). Finally, 5-chloro-3-nitro-2-vinylpyridine (1 g) was prepared from 5-chloro-3-nitropyridine-2-carbaldehyde (0.72 g, 72% yield) with reference to the method of Example 61.

References

[1] Patent: WO2008/144275, 2008, A1. Location in patent: Page/Page column 105

5-Chloro-3-nitropyridine-2-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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1086838-13-2, 5-Chloro-3-nitropyridine-2-carboxaldehydeRelated Search:

5-Chloro-3-nitropyridine-2-carboxaldehyde

5-Chloro-3-nitropicolinaldehyde

2-Pyridinecarboxaldehyde, 5-chloro-3-nitro-

5-chloro-3-nitropyridine-2-carbaldehyde

1086838-13-2