5-Chloro-3-nitropyridine-2-carboxaldehyde
- Product Name
- 5-Chloro-3-nitropyridine-2-carboxaldehyde
- CAS No.
- 1086838-13-2
- Chemical Name
- 5-Chloro-3-nitropyridine-2-carboxaldehyde
- Synonyms
- 5-Chloro-3-nitropicolinaldehyde;5-chloro-3-nitropyridine-2-carbaldehyde;5-Chloro-3-nitropyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde, 5-chloro-3-nitro-
- CBNumber
- CB12629929
- Molecular Formula
- C6H3ClN2O3
- Formula Weight
- 186.55
- MOL File
- 1086838-13-2.mol
5-Chloro-3-nitropyridine-2-carboxaldehyde Property
- Boiling point:
- 289.2±40.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.49±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2311DW
- Product name
- 5-Chloro-3-nitropicolinaldehyde
- Packaging
- 10g
- Price
- $2665
- Updated
- 2021/12/16
- Product number
- A154570
- Product name
- 5-Chloro-3-nitropicolinaldehyde
- Purity
- 95+%
- Packaging
- 50mg
- Price
- $107
- Updated
- 2021/12/16
- Product number
- A154570
- Product name
- 5-Chloro-3-nitropicolinaldehyde
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $178
- Updated
- 2021/12/16
- Product number
- A154570
- Product name
- 5-Chloro-3-nitropicolinaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $257
- Updated
- 2021/12/16
- Product number
- A154570
- Product name
- 5-Chloro-3-nitropicolinaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
5-Chloro-3-nitropyridine-2-carboxaldehyde Chemical Properties,Usage,Production
Synthesis
1086838-15-4
1086838-13-2
The general procedure for the synthesis of 5-chloro-3-nitropyridine-2-carbaldehyde from the compound (CAS:1086838-15-4) is as follows: first, 2-amino-3-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)-2-methylpropanenitrile (39 mg) was prepared in quantitative amounts according to a method similar to that described in the preceding. Referring to the operation of Example 1 part b, but using 1-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)propan-2-one (32 mg) as a starting material. 1-(6-chloro-3-methoxy-2H-pyrazolo[4,3-b]pyridin-2-yl)propan-2-one was prepared similarly as described in Example 105. Next, the method of Example 136 parts a to d was followed, but using 5-chloro-3-nitropyridine-2-carboxaldehyde (1.2 g) and decaborane from part a to prepare [2-(tert-butyldimethylsilyloxy)propyl]-(5-chloro-3-nitropyridin-2-yl)methanamine (0.4 g in 17% yield). 5-chloro-3-nitropyridine-2-carboxaldehyde was prepared similarly to that described in Example 136 parts a to c, with the difference that one starts with 2-amino-5-chloro-3-nitropyridine in part a or uses commercially available 2-bromo-5-chloro-3-nitropyridine as a starting material for part b. The method of preparing 5-chloro-3-nitropyridine-2-carbaldehyde is similar to that described in Example 136 parts a to c. Additionally, the ozonolysis step of part c can be replaced by oxidative cracking using a 4% aqueous osmium tetroxide solution (2 mL) and sodium periodate (1.2 g) in a mixture of THF and water (10:1, 20 mL). Finally, 5-chloro-3-nitro-2-vinylpyridine (1 g) was prepared from 5-chloro-3-nitropyridine-2-carbaldehyde (0.72 g, 72% yield) with reference to the method of Example 61.
References
[1] Patent: WO2008/144275, 2008, A1. Location in patent: Page/Page column 105
5-Chloro-3-nitropyridine-2-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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