c-GpAp
- Product Name
- c-GpAp
- CAS No.
- 849214-04-6
- Chemical Name
- c-GpAp
- Synonyms
- cGAMP;c-GpAp;di-GAMP;di-cGAMP;3'3'-cGAMP;3'3'-cGAMP;Cyclic GMP-AMP;cGAMP free acid;cGAMP ammonium salt;cGAMP 3',3'-cGAMP
- CBNumber
- CB12695700
- Molecular Formula
- C20H24N10O13P2
- Formula Weight
- 674.41
- MOL File
- 849214-04-6.mol
c-GpAp Property
- Boiling point:
- 1159.9±75.0 °C(Predicted)
- Density
- 2.61±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- powder
- pka
- 0.96±0.70(Predicted)
- color
- white to beige
- Water Solubility
- Water : 20 mg/mL (29.66 mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1232
- Product name
- cGAMP sodium salt
- Purity
- ≥98% (HPLC)
- Packaging
- .5UMO
- Price
- $211
- Updated
- 2023/06/20
- Product number
- G110500
- Product name
- c-GpAp
- Packaging
- 10mg
- Price
- $13390
- Updated
- 2021/12/16
- Product number
- CS-3892
- Product name
- cGAMP
- Purity
- 99.22%
- Packaging
- 10mg
- Price
- $2150
- Updated
- 2021/12/16
- Product number
- CS-3892
- Product name
- cGAMP
- Purity
- 99.22%
- Packaging
- 25mg
- Price
- $3750
- Updated
- 2021/12/16
- Product number
- NC137624
- Product name
- 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate
- Packaging
- 500ug
- Price
- $300
- Updated
- 2021/12/16
c-GpAp Chemical Properties,Usage,Production
Uses
cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.
Uses
c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.
Definition
ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).
Biochem/physiol Actions
cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.
storage
+4°C
c-GpAp Preparation Products And Raw materials
Raw materials
Preparation Products
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